摘要
目的探讨β-连环蛋白(β-catenin)和轴蛋白(Axin)在卵巢癌组织中表达情况及其临床意义。方法应用免疫组织化学染色法检测42例卵巢上皮细胞癌、20例卵巢良性肿瘤组织标本中β-catenin和Axin蛋白的表达情况,分析β-catenin、Axin表达与卵巢癌临床病理因素的关系。结果卵巢上皮细胞癌组织中β-catenin的异常表达率明显高于卵巢上皮性良性肿瘤组织(P<0.05),Axin阳性表达率明显低于卵巢上皮性良性肿瘤组织(P<0.05);β-catenin和Axin在卵巢上皮细胞癌中的表达呈负相关性(r=-0.442,P<0.05);β-catenin异常表达率和Axin阳性表达率与卵巢上皮细胞癌临床分期、组织学分级、有无淋巴结转移密切相关(P均<0.05),而与病理类型无明显关系(P均>0.05)。结论β-catenin、Axin表达与卵巢癌临床分期、组织学分级及淋巴结转移有关,β-catenin、Axin可作为预测卵巢癌侵袭转移及预后的指标。
Objective It is to explore the beta serial protein （ β- catenin） and axis （ Axin） protein expression in ovarian epithelial carcinoma tissue and its clinical significance. Methods The expression of β -catenin and Axin protein was detected in the tissue examples of 42 patients with ovarian epithelial carcinoma, 20 cases of ovarian benign tumor by immunohistochemical staining method, the relationship of β- catenin, Axin expression with clinical pathological factors of ovarian cancer were ana-lyzed. Results In ovarian epithelial carcinoma tissue the abnormal expression rate of β -catenin was obviously higher while the positive expression rate of Axin was significantly lower than that in epithelial ovarian benign tumor tissue （P 〈0. 05） ; β- catenin and Axin expression in ovarian epithelial carcinoma showed a negative correlation （r = 0.442, F 〈0.05） ; β -catenin ab-normal expression rate and Axin positive expression rate was closely related to clinical stage, histological grade, the presence of lymph node metastasis of ovarian epithelial carcinoma （P 〈0. 05） , but not obviously related with pathologic types （P 〉 0. 05 ）. Conclusion β - catenin,Axin expression was related to clinical stage, histological grade and lymph node metastasis of ovarian carcinoma,β - catenin, Axin can be used as index of predicting invasion, metastasis and prognosis of ovarian cancer.
出处
《现代中西医结合杂志》
CAS
2017年第26期2871-2873,2957,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
