中性粒细胞/淋巴细胞比值与良性前列腺增生临床进展相关性研究

Study on Correlation Between Neutrophil/lymphocyte Ratio and Progression of Benign Prostatic Hyperplasa

目的评价应用中性粒细胞/淋巴细胞比值(NLR)预测良性前列腺增生(BPH)患者进展。方法选择2014年10月—2016年3月在同煤二院因下尿路症状就诊的120例患者为研究对象,平均年龄58岁。全血细胞计数、前列腺特异性抗原(PSA)、红细胞沉降率(ESR)、C反应蛋白(CRP)被检测。NLR和PSA、CRP、ESR、前列腺体积、国际前列腺症状评分(IPPS)、最大尿流率(Qmax)之间的相关性分析。结果 NLR(2.25±1.2)和IPPS(18.5±7)、PSA(2.7±0.9)ng/mL存在正相关性,与Qmax呈现负相关性(12±3)mL/s。依据IPPS,PSA和Qmax,高风险组患者有较高的NLR。结论 NLR与BPH患者临床进展呈正相关性。

Objective To assess the utility of the neutrophil-lymphocyte ratio （NLR） as a simple and readily available predictor for clinical disease activity in patients with benign prostate hyperplasia （BPH）. Methods We examined 120 consecutive patients （October 2014-March 2016） admitted to our outpatient clinic with of the lower urinary tract. The mean age was 58 years. Complete blood count （CBC）, prostate-specific antigen （PSA）, erythrocyte sedimentation rate （ESR）, and C-reactive protein （CRP） were assessed. Correlations between PSA, CRP, ESR, prostate volume, Interna-tional Prostate Symptom Score （IPPS）, maximum urinary flow rate （Qmax）, and NLR were assessed statistically. Results NLR （2.25 ±1.2） was positively correlated with IPSS （18.5 ±7）, PSA （2.7 ±0.9）ng/mL, and negatively correlated with Qmax （12±3）mL/s. High-risk patients a had a higher NLR compared with low-risk patients, based on IPSS, PSA, and Qmax. Conclusion Our results indicate that NLR is associated with clinical status in BPH patients and suggest that NLR can give information along with lower urinary tract symptoms （ LUTS） severity which may be used as a readikly accessible marker for patient follow-up.