摘要
目的分析急性非ST段抬高型心肌梗死患者copeptin及cTnI表达及其诊断意义。方法随机选取2013年1月—2015年1月该院收治的55例急性非ST段抬高型心肌梗死患者,分为研究组(55例),并选择50例心绞痛患者,将其作为对照组(55例),对两组检测诊断其copeptin(肽素)及cTnI(肌钙蛋白I)表达,分析临床诊断急性非ST段抬高型心肌梗死中copeptin及cTnI表达的意义。结果对于研究组中患者,其copeptin、cTnI表达阳性率显著高于对照组差异有统计学意义(P<0.05);同时,当copeptin诊断临界点时为0.85 pmol/L,灵敏度为90%,特异度达到64%,cTnI诊断临界点为0.05 ng/mL,灵敏度为42.5%,特异度94.1%;联合两项指标诊断急性非ST段抬高型心肌梗死,有助于提高临床诊断的阴性预测值。结论在临床诊断急性非ST段抬高型心肌梗死中,可以将copeptin及cTnI表达作为临床诊断指标,根据检测copeptin、cTnI表达有助于提升临床诊断急性非ST段抬高型心肌梗死的特异度与灵敏度,在临床中发挥重要诊断意义。
Objective Copeptin and cTnI Expression and diagnostic significance of acute non-ST segment elevation myocardial infarction. Methods Randomly selected in January 2013 to January 2015 in our hospital 55 cases of acute non-ST segment elevation myocardial infarction were divided into study group （55 cases）, and 50 cases of angina pec-toris, as a control group （55 cases）, two groups of detection and diagnosis of their copeptin （peptide hormone） and cTnI （troponin I） expression analysis of clinical significance in diagnosis of acute non-ST segment elevation myocardial in-farction copeptin and cTnI expression. Results For the study group patients, copeptin, cTnI expression positive rate was significantly higher （P〈0.05）; At the same time, in order to diagnose the critical point when copeptin 0.85 pmol/L, the sensitivity was 90% and specificity reached 64%, cTnI diagnosis of a critical point of 0.05 ng/mL, sensitivity was 42.5%, specificity 94.1%; two indicators joint diagnosis of acute non-ST segment elevation myocardial infarction, help to improve the negative predictive value of clinical diagnosis. Conclusion The clinical diagnosis of acute non-ST seg-ment elevation myocardial infarction, and can be expressed copeptin cTnI as a clinical diagnostic criteria, based on the detection copeptin, cTnI expression contributes to enhance the clinical diagnosis of acute non-ST segment elevation myocardial infarction specificity and sensitivity plays an important significance in clinical diagnosis.
出处
《系统医学》
2016年第9期50-52,共3页
Systems Medicine
