小儿支气管哮喘急性发作与肺炎支原体感染的相关性研究

The Relationship between Acute Attack of Bronchial Asthma and Mycoplasma Pneumoniae Infection in Children

目的探讨小儿支气管哮喘急性发作与肺炎支原体感染的相关性。方法于2013年1月—2015年12月,选取60例小儿支气管哮喘急性发作患者作为观察组,选取60例非哮喘小儿呼吸道感染患者作为对照组,所有患者均接受肺炎支原体血清学检测,并对观察组患者的血清免疫球蛋白E、嗜酸性粒细胞进行测定。比较两组患者的肺炎支原体阳性表达率,对观察组肺炎支原体阴性与阳性表达患者的免疫球蛋白E、嗜酸性粒细胞进行比较,并计算肺炎支原体感染与小儿支气管哮喘急性发作之间的相关性系数。结果观察组的肺炎支原体阳性表达率为46.67%,较之对照组的28.33%明显更高(P<0.05)。观察组肺炎支原体阳性患者的免疫球蛋白E、嗜酸性粒细胞分别为(651.96±157.84)U/m L、(489.25±63.58)×109,与观察组肺炎支原体阴性患者相比,差异具有统计学意义(P<0.05)。肺炎支原体感染与小儿支气管哮喘的急性发作密切相关(P<0.05),且呈正相关。结论小儿支气管哮喘的急性发作与肺炎支原体感染密切相关,临床诊断小儿支气管哮喘时可将肺炎支原体检测作为标记物,以提高诊断的准确性。

Objective To explore the relationship between acute attack of bronchial asthma and Mycoplasma pneumoniae infection in children. Methods In January 2013 — December 2015, 60 cases of children with bronchial asthma were selected as the observation group, and 60 cases of non asthmatic children with respiratory tract infections were selected as the control group. All patients were received Mycoplasma pneumoniae serological test, and the immunoglobulin E protein and eosinophile granulocyte in the observation group were determined. The mycoplasma pneumonia positive expression rates were compared between the two groups, the immunoglobulin E protein and eosinophile granulocyte of patients with mycoplasma pneumonia with positive and negative expression in the observation group were compared,and the correlation coefficient of mycoplasma pneumoniae infection and bronchial asthma acute attack was calculated.Results The positive rate of pneumonia in the observation group was 46.67%, was higher than that of the control group of 28.33%（P0.05）. The immunoglobulin E protein and eosinophile granulocyte of Mycoplasma positive patients in the observation group were respectively（651.96 ± 157.84） U / m L,（489.25 ± 63.58） × 109, and compared with Mycoplasma negative patients in the observation group, the difference was statistically significant（P〈0.05）. Mycoplasma pneumoni-ae infection was closely related to the acute attack of bronchial asthma in children（P0.05）, and was positively correlated. Conclusion The acute attack of bronchial asthma in children is closely related to the infection of Mycoplasma pneumoniae, Mycoplasma pneumoniae detection can be used in the clinical diagnosis of bronchial asthma with children as a marker, to improve the accuracy of diagnosis.