TP化疗方案对非小细胞肺癌患者血糖代谢的影响

Effect of TP Chemotherapy on Blood Glucose Metabolism in Patients with Non-small Cell Lung Cancer

目的探讨和分析在非小细胞肺癌(NSCLC)患者的治疗过程当中采用TP化疗方案对其血糖代谢情况的影响。方法随机抽选该院2014年1月—2016年1月以来,在呼吸内科接受TP化疗方案进行的临床治疗的非小细胞肺癌患者43例,并对患者第1周期及第3周期的血糖代谢况,FPG(空腹血糖)、2h PG(餐后2 h血糖)和Hb A1c(糖化血红蛋白)指标值进行回顾性统计分析。结果患者第3周期化疗后的FPG平均值为(7.93±1.62)mmol/L,2h PG平均值为(9.51±1.60)mmol/L,Hb A1c平均值为(6.50±0.74)%,均显著高于第1周期各指标值,差异具有统计学意义(P<0.05)。结论非小细胞肺癌患者在临床治疗中应用TP化疗方案,易致血糖升高,此过程存在多种机制,在化疗过程中应对血糖代谢情况予以密切观察,及时控制血糖水平。

Objective To investigate and analyze the clinical effect of TP chemotherapy regimen on blood glucose metabolism in patients with NSCLC. Methods Randomly selected in our hospital in January 2014 to January 2016, 43 patients with NSCLC diagnosis and treatment of patients in the Department of Respiration Medicine in our hospital.Treated them with TP chemotherapy regimens, and the patients＇ first cycle and third cycle of blood glucose metabolism,including values of FPG,2h PG and Hb Alc were statistically compared and analyzed. Results The values of FPG（7.93±1.62）mmol/L, 2h PG（9.51±1.60）mmol/L and Hb A1c（6.50±0.74）% indexes at the first week were significantly higher than those at the third week, and the comparison was statistically significant（P〈0.05）. Conclusion Application in clinical diagnosis and treatment of NSCLC patients in TP chemotherapy regimens, easily to cause the patient＇s blood sugar rises, there are many mechanisms in this process;therefore, the blood glucose level should be closely monitored of in clinical treatment.