细胞因子在2型糖尿病患者感染时的变化探析

Cytokines Detect Changes in Type 2 Diabetes Patients with Infection

目的研究分析细胞因子在2型糖尿病患者感染时变化情况。方法随机选取2014年1月—2016年1月该院收治的2型糖尿病且发生感染的患者66例作为观察对象,并选取同期未发生感染的患者66例作为对照组,分析两组患者细胞因子以及空腹血糖和餐后2 h血糖的变化,并积极予以治疗,在对比治疗前后细胞因子在2型糖尿病患者中的变化。结果两组患者的空腹血糖和餐后2 h血糖比较差异无统计学意义(P>0.05),而观察组患者和对照组患者分别为TNF-α(肿瘤坏死因子)(373.54±12.54)mg/L,(103.54±6.58)mg/L、h-CRP(超敏C反应蛋白)(19.67±6.75)mg/L,(6.15±3.05)mg/L、IL-2(白介素-2)(105.23±11.03)mg/L,(68.15±5.19)mg/L以及IGF-I(胰岛素样生长因子)(145.12±19.03)mg/L,(96.35±11.08)mg/L等细胞因子水平均显著较对照组高,组间差异有统计学意义(P<0.05),并且观察组患者经过一系列抗感染治疗后,患者的上述细胞因子水平均呈下降趋势,差异有统计学意义(P<0.05)。结论细胞因子水平的变化可以作为2型糖尿病患者感染发生的重要标志之一。

Objective To study the analysis of cytokines in patients with type 2 diabetes hospital infection changes.Methods Randomly selected from January 2014 to January 2016 in our hospital patients with type 2 diabetes and 66 cases of infection in patients as observation object and choose the same period 66 cases of infection did not occur as a control group, two Analysis Cytokines group of patients and changes in fasting plasma glucose and 2-hour postprandial blood glucose and actively be treated, cytokine changes before and after treatment in type 2 diabetic patients. Results The fasting plasma glucose and 2-hour postprandial blood glucose difference between the two groups were not statistically significant(P > 0.05), while the observation group were TNF-α(tumor necrosis factor)(373.54 ±12.54)mg/L,(103.54 ±6.58)mg/L, h-CRP(high-sensitivity C-reactive protein)(19.67 ±6.75)mg/L,(6.15 ±3.05)mg/L, IL-2(interleukin-2)(105.23±11.03)mg/L,(68.15±5.19)mg/L and IGF-I(insulin-like growth factor)(145.12±19.03)mg/L,(96.35±11.0)mg/L and other cytokines were significantly higher in the control group, the difference between groups by statistical analysis showed that there were significant(P <0.05), and the observation group patients after a series of anti-infective therapy, said cytokine levels were decreased in patients, statistically significant differences(P <0.05). Conclusion The changes of cytokine levels can be used as an important sign of infection in patients with type 2 diabetes occurred.