盐酸右美托咪定与酒石酸布托啡诺联合用于重症患者镇静镇痛效果的临床观察

Dexmedetomidine Hydrochloride Combined with Tartaric Acid Bhutto Butorphanol Analgesia in Patients with Severe Sedation

目的分析盐酸右美托咪定与酒石酸布托啡诺联合应用于重症患者治疗中的镇静镇痛效果。方法回顾性分析该院2015年1月—2016年1月期间收治的64例重症患者的临床资料,按照入院顺序分为研究组(32例)与对照组(32例)。研究组给予盐酸右美托咪定与酒石酸布托啡诺联合镇痛治疗,对照组给予咪达唑仑与酒石酸布托啡诺联合镇痛治疗;对比两组重症患者的谵妄发生率、用药后唤醒时间、镇痛时间与治疗前后血压、呼吸以及心率状况。结果该研究中,研究组32例重症患者的谵妄发生率、用药后唤醒时间、镇痛时间分别为6.25%、(3.18±1.98)min、(25.61±3.17)min,对照组依次为40.63%、(10.68±3.59)min、(32.57±5.18)min,研究组的谵妄发生率、用药后唤醒时间、镇痛时间显著优于对照组,差异有统计学意义(P<0.05)。研究组治疗之后的收缩压、舒张压以及心率分别为(51.2±6.5)mm Hg、(92.4±8.5)mm Hg、(91.1±5.2)次/min,对照组依次为(58.7±5.8)mm Hg、(102.6±9.4)mm Hg、(96.4±6.8)次/min,研究组治疗之后的收缩压、舒张压以及心率显著优于对照组,差异有统计学意义(P<0.05)。结论盐酸右美托咪定与酒石酸布托啡诺联合应用于重症患者治疗中的镇静镇痛效果十分显著,值得在临床治疗中推广运用。

Objective To study the sedative and analgesic effects of dexmedetomidine hydrochloride and tartaric acid Bhutto butorphanol used in the treatment of patients with severe. Methods The clinical data of 64 patients admitted to our hospital from January 2015 to January 2016 were retrospectively analyzed. The patients were divided into the study group(32 cases) and the control group(32 cases) according to the order of admission. The study group was given dexmedetomidine hydrochloride and tartaric acid Bhutto butorphanol analgesia treatment, the control group was given midazolam and tartaric acid Bhutto butorphanol analgesia treatment; compared two groups of patients with severe delirium after medication, wake-up time, duration of analgesia and blood pressure before and after treatment, breathing and heart rate. Results In this study, the team of 32 patients with severe incidence of delirium, medication after wake up time, analgesia was 6.25%,(3.18±1.98) min and(25.61±3.17) min and in control group 40.63%,(10.68±3.59) min and(32.57±5.18) min, the team the incidence of delirium, wake up of time, the medicine analgesia time significantly better than control group, the difference was statistically significant(P < 0.05). Group after the treatment of systolic pressure,diastolic blood pressure and heart rate(51.2±6.5) mm Hg, respectively(92.4±8.5) mm Hg,(91.1±5.2) times/min, the con-trol group was(58.7±5.8) mm Hg,(102.6±9.4) mm Hg,(96.4±6.8) times/min, the team after the treatment of systolic pressure, diastolic blood pressure and heart rate was significantly better than control group, the difference was statistically significant(P < 0.05). Conclusion The sedative and analgesic effects of dexmedetomidine hydrochloride and tartaric acid Bhutto butorphanol used in the treatment of critically ill patients is significant, it is worthy of promotion and use in clinical treatment.