阿司匹林抵抗对大动脉粥样硬化性脑梗死复发的影响

The Effect of Aspirin Resistance on the Recurrence of Atherosclerotic Cerebral Infarction

目的研究阿司匹林抵抗对大动脉粥样硬化性脑梗死患者复发脑梗死的影响。方法对2015年1月—2015年3月粥样硬化的脑梗死患者测定入院日血小板聚沉率,并每晚睡前1h给予阿司匹林肠溶片100 mg,连服7 d后再复测血小板聚沉率。随机各选取30例阿司匹林敏感者和抵抗者,治疗后随访1年观察脑梗死复发情况。结果阿司匹林抵抗者1年内脑梗死复发率66.67%(20/30),与阿司匹林敏感者脑梗死复发率16.67%(5/30)比,差异有统计学意义(P<0.05)。结论阿司匹林抵抗大动脉粥样硬化脑梗死患者非常易再次发生脑梗死,在日常看护和维持治疗中应注意再次发生脑梗死的预防。

Objective To study the effect of aspirin resistance on the recurrence of cerebral infarction in patients with atherosclerotic cerebral infarction. Methods on January 2015 — March 2015 atherosclerosis in patients with cerebral infarction were determined on the admission day and platelet coagulation rate, and every night before going to bed one hour given aspirin enteric coated tablets 100 mg, even served 7 days later again to measure platelet coagulation rate. Randomly selected 30 patients with aspirin sensitivity and resistance, after treatment for 1 years to observe the recurrence of cerebral infarction. Results The recurrence rate of cerebral infarction within 1 years was 66.67%(20/30), and the recurrence rate was 16.67%(5/30), and the difference was statistically significant(P<0.05). Conclusion Aspirin resistance in patients with cerebral infarction is very easy to occur again after cerebral infarction, in the daily care and maintenance treatment should pay attention to the prevention of recurrence of cerebral infarction.