klotho蛋白与疾病的研究进展

Research Progress of Klotho Protein and Disease

klotho基因主要存在于肾脏及脑组织中,通过基因表达,产生两种蛋白物质:(1)膜结合型蛋白,即膜结合受体;(2)分泌型蛋白,即体液调节因子。以上两种蛋白物质,均对心血管疾病起到显著的保护效果,其作用途径为调节机体相关元素代谢,比如维生素D,再比如钙和磷等元素。另外,两种蛋白物质在抗衰老过程中的作用也不可忽视。据相关报道显示,klotho蛋白对人体的影响,还涉及到肾损伤、癌症以及其他代谢疾病。

Klotho Gene exists mainly in the kidney and brain tissues by gene expression, resulting in two kinds of protein substances:(1) membrane bound protein that membrane-bound receptor;(2) secretion type protein, namely humoral regulation factor. The above two kinds of protein substances, on cardiovascular disease to significant protective effect and its mechanism of regulating the body element metabolism, such as vitamin D, such as calcium and phosphorus elements. In addition, two kinds of protein substances in anti-aging process role can not be ignored. According to the relevant reports indicate that Klotho protein on the human body, but also related to renal injury, cancer and other metabolic diseases In the following.