非特异性腰背痛患者血清骨性碱性磷酸酶的水平研究

Study of the bone alkaline phosphatase in patients who suffer from have got non-specific low back pain

目的:研究非特异性腰背痛患者血清骨性碱性磷酸酶的水平,探讨两者可能的存在的相关性。方法:选取105例(均为汉族)就诊疼痛科门诊并被确诊为非特异性腰背痛的患者作为病例组,同时招募体检健康人40位作为对照组,记录两组体重、身高、BMI等一般资料,抽取外周静脉血1~2 ml,检测血沉(erythrocyte sedimentation rate,ESR)、C-反应蛋白(C reactive protein,CRP)、及骨性碱性磷酸酶(bone alkaline phosphatase,BALP),病例组还需完成RMDQ(Roland-Morris disable question)问卷及VAS(visual analogue scale,VAS)评分,数据检测及收集完成后,根据VAS评分分值,分为三组,A组VAS评分1~3分,B组VAS评分4~6分,C组VAS评分7~10分,分析数据。结果:最终参与研究的非特异性腰背痛患者72位,对照组28位(因感染、骨折、信息丢失等原因排除)。非特异性腰背痛患者组的BALP均>150 u/l,且均数高于对照组,差异有统计学意义(P<0.05),A组、B组及C组的BALP水平组间比较,差异无统计学意义(P>0.05);C组的RMDQ量表分值高于A组、B组,且A组低于B组,差异有统计学意义(P<0.05);RMDQ分值与VAS评分的相关系数r为0.739,差异有显著统计学意义(P<0.01)。结论:非特异性腰背痛患者的BALP高于正常值,但两者并无显著相关性,还需进一步探讨研究。

Objective To study the effects of the bone alkaline phosphatase in patients who suffer non-specific low back pain with or without radiation into limbs,their possible relationship with BMI,RMDQ,and VAS. Method A total of 105 consecutive patients with non-specific low back pain were taken part in this study. and 40 health persons were recruited as control group. To record everyone＇s general information,like age,tall,BMI. Then draw everyone＇s vein blood 1 ~ 2 ml,to test erythrocyte sedimentation rate,C reactive protein and bone alkaline phosphatase. And to complete the scales of RMDQ and VAS test the level of pain and influence on patients＇ life in experimental group,According VAS grade divided into three groups： group A： VAS grade 1 ~ 3,group B： VAS grade 4 ~ 6,group C： VAS grade 7 ~ 10,the data was analyzed. Results In the end,there were 72 NLBP patients and 28 health persons taken in the study,because there need excluded infection,fracture and miss information and so on. Compared with the control group,the dose of BALP was lower than the experimental group（ P〈0. 05）; Group A,group B and group C had no significance difference（ P〉0. 05）,The group C higher at RMDQ than group A and group B,and which was lower in group A than group B（ P〈0. 05）. The RMDQ and VAS of medical record group correlation index was 0. 739（ P〈0. 01）. Conclusion The level of bone alkaline phosphatase in the patients with non-specific LBP is not common,need further investigation