广州地区正常儿童血清叶酸参考区间调查

Investigation of the Normal Reference Range for Serum Folate of Healthy Children in Guangzhou Region

目的建立广州地区健康儿童血清叶酸的参考区间。方法应用LK3000V维生素检测仪对广州地区1 860名健康儿童(男性1 061例,女性799例)和129例成年人(男性52例,女性77例)的血清叶酸进行检测,对结果进行统计分析。结果①11岁以内的11个年龄组、11~17岁和成人组血清叶酸水平均无性别差异(P>0.05)。②血清叶酸水平(中位数(P_(2.5),P_(97.5))0~1岁(含1岁,下同)组、1~17岁组、成人组分别为9.39(6.12,14.85)nmol/L,,10.65(6.05,16.52)nmol/L和11.12(6.3,17.51)nmol/L,两两比较差异有统计学意义(P<0.05)。③年龄与血清叶酸水平无明显相关性(r=0.039,P=0.09)。结论广州地区正常儿童血清叶酸水平的参考区间为1岁以内(含1岁)为6.12~14.85 nmol/L,1岁~17岁为6.05~16.52 nmol/L。

Objective To establish the normal reference range for serum folate of healthy children in Guangzhou region. Methods Levels of serum folate of 1 860 healthy children （1 061 males and 799 females） and 129 adults （52 males and 77 fe- males） living in Guangzhou region were examined by LK3000V Vitamin Analyzer. Then the data were analyzed with statisti- cal methods. Results （1）There was no statistical difference between boys and girls for levels of serum folate in every group defined by age （P〉0.05）. （2）The levels of serum folate Emedian（P2.5 ,P97.5 ）1 defined by age were as follows：9.39 （6.12, 14.85） nmol/L for 0-1 year-old group,10.65 （6.05,16.52） nmol/L for 1.01-17 year-old group and.11.12 （6.3,17.51） nmol/L for the adult group. Statistical difference was found between any two groups of the three （P〈0.05）. （3）No statisti- cal correlation was found between age and the level of serum folate （r=0. 039,P=0.09）. Conclusion Reference range for serum folate for healthy children in Guangzhou region include two parts： 6.12-14.85 nmol/L for 0- 1 year-old group and 6.05-16.52 nmol/L for 1.01-17 year-old group.