西安地区女性尖锐湿疣患者人乳头瘤病毒分型及与复发关系分析

Study on Relationship of Human Papillomavirus Genotyping and Recrudescence for Female Patients with Condyloma Acuminatum in Xi'an

目的检测西安地区女性尖锐湿疣患者中人乳头瘤病毒(HPV)感染情况、基因亚型,及不同基因型别与临床复发的关系。方法采用PCR-反向点杂交技术,检测63例女性尖锐湿疣患者疣体脱落细胞中的HPV基因型。结果 63例尖锐湿疣检出61例HPV阳性,阳性率96.83%,主要感染型别依次为HPV6(59.2%),11(22.95%),42(8.20%),43(8.20%),52(8.20%),16(6.56%)和18(4.92%)等。43例单一型HPV感染占70.49%(43/61),混合感染1例,占22.95%(14/61);61例患者采用激光治疗,3月后观察复发情况,发现高危组复发率66.67%及混合感染组复发率71.43%明显高于低危组复发率48.78%。结论西安地区女性尖锐湿疣患者HPV基因型主要以低危型HPV6,11为主,多重型别HPV的混合感染及高危型别感染是西安地区女性尖锐湿疣复发的危险因素。

Objective To determine the genotypes of human papillomavirus （HPV） and to estimate their recurrence of condy- loma acuminatum （CA） among female in Xi＇ an. Methods HPV genotype was detected with human papilloma virus genoty- ping kit in 63 female patients with CA. Follow-up was carried out to observe the recurrence of CA in these patients after CO2 laser treatment. Results Of the 63 specimens,61 （96.83%） were positive for HPV,and a total of 16 HPV subtypes were i- dentified. The predominant genotypes were HPV6 （59.2%）, 11 （22.95%）, 42 （8.20%）, 43 （8.20%）, 52 （8.20%）, 16 （6.56%） and 18 （4.92%） respectively. 43 cases of single HPV infection was accounted for 70.49% （43/61） ,mixed infec- tion in 14 cases was accounted 22.95 % （14/61）. 61 cases of patients with laser treatment,observing the recurrence of cuses after 3-month later,it was found that the recurrence rate in higher risk group and mixed infection group was higher than that in low-risk group. Conclusion HPV6,11 is main HPV infection type of the female patients in Xi＇ an, the recurrence of CA is higher in patients with high risk HPV than in those with low risk HPV and mixted infection. Mixted infection of HPV and high-risk HPV is a risk factor for recurrence of female genital warts in Xi＇an region.