RAS抑制剂的骨生物学作用研究进展

Research progress on the bone biological effects of RAS inhibitors

近来研究显示,骨组织、骨细胞存在肾素-血管紧张素系统(RAS)组分。功能性研究发现骨骼RAS参与了骨质疏松症的发生、发展,充分揭示了骨骼RAS在骨代谢中的重要作用。本文综述了血管紧张素转化酶抑制剂、血管紧张素受体拮抗剂对骨代谢的改善作用与不利影响。本文有助于更好地理解组织RAS在调控骨健康中的生物学作用,为临床应用RAS抑制剂治疗高血压或糖尿病并发症患者的用药具有指导意义。

Recent studies have revealed the existence of renin-angiotensin system（ RAS） components in bone tissue and bone cells. Functional studies demonstrated the involvement of skeletal RAS in the occurrence and development of osteoporosis,suggesting the important roles of skeletal RAS on bone metabolism. In this reviewwe summarized the beneficial and detrimental effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on bone metabolism. The information from this reviewwill be valuable for the better understanding of the biological effects of local RAS on bone health,as well as provide clinical guidance when the RAS inhibitors are prescribed for patients with hypertension or diabetic complications.