强化神经营养方案辅助胰岛素对糖尿病周围神经病变患者治疗及预后的影响

Effect of insulin supplementation with enhanced neurotrophic regimen on treatment and prognosis in patients with diabetic and peripheral neuropathy

目的:分析强化神经营养方案辅助胰岛素对糖尿病周围神经病变患者治疗及预后的影响。方法:将2015年1月至2016年8月期间收治的糖尿病周围神经病变患者105例按随机分配原则,将所有患者分入到观察组(53例)和对照组(52例)。对照组采用常规胰岛素治疗,观察组采用强化神经营养联合胰岛素方案。观察两组治疗的效果。结果:观察组治疗总体有效率高达90.57%,而对照组为75.47%,两者差异具有统计学意义(P<0.05)。治疗前,两组患者神经传导速度及氧化应激指标差异均无统计学意义(P>0.05)。治疗后,两组患者的各指标得到明显改善,且观察组患者的感觉、运动神经传导速度及氧化应激指标的改善效果显著优于对照组,差异具有统计学意义(P<0.05)。结论:强化神经营养方案辅助胰岛素治疗糖尿病周围神经病变的患者,可以显著提高神经传导速度,降低机体内氧化应激反应,提高治疗效果。

Objective： To analyze the effects of insulin supplementation with enhanced neurotrophic regimen treatment and prognosis in patients with diabetic and peripheral neuropathy. Methods： A total of 105 patients with diabetic and peripheral neuropathy who were treated from January 2015 to August 2016 were divided into an observation group （53 cases） and a control group （52 cases） according to the principle of random assignment. The control group was treated with routine insulin therapy, and the observation group was given supplemental insulin supplemented with enhanced neurotrophy. The effects of the treatment between the two groups were observed. Results： The total effective rate of the observation group was 90.57%, while that of the control group was 75.47%, which had a statistically significant difference （P〈0.05）. Before treatment, there was no significant difference in nerve conduction velocity and oxidative stress between the two groups （P〉0.05）. After treatment, the indexes of the two groups were significantly improved, and the effect of the sensory, motor nerve conduction velocity and oxidative stress of the observation group was significantly better than that of the control group （P〈0.05）. Conclusion： Enhanced neurotrophic program and insulin supplementation in patients with diabetic and peripheral neuropathy can significantly improve nerve conduction velocity and reduce oxidative stress in vivo, which improve the therapeutic effect. It is worth to promote the use.