CD3^+,CD4^+及CD8^+T淋巴细胞数目改变作为早期诊断脓毒血症指标可行性的Meta分析

Change of CD3^+, CD4^+ and CD8^+ T-lymphocyte subset in the early diagnosis of sepsis: a Meta-analysis

目的:评价脓毒血症CD3^+,CD4^+及CD8^+T淋巴细胞数目的改变以帮助早期诊断。方法:计算机检索Medline,Pub Med,SPINGER,John Wiley,Science Direct,EBSCO,知网以及万方数据库,检索时限均为建库至2017年2月,收集关于脓毒血症CD3^+,CD4^+及CD8^+T淋巴细胞数目改变的病例对照研究。由2位研究者按照纳入和排除标准独立筛选文献、提取资料和评价质量后,用Rev man5.3软件进行Meta分析。评价早期脓毒血症患者CD3^+,CD4^+及CD8^+T淋巴细胞数目与对照组的差异。结果:早期脓毒血症患者CD3^+,CD4^+及CD8^+T淋巴细胞数目均比对照组人群低,差异有统计学意义(P<0.05);死亡组脓毒血症患者CD3^+,CD4^+及CD8^+T淋巴细胞数目均比存活组病人低,差异有统计学意义(P<0.05)。结论:CD3^+,CD4^+及CD8^+T淋巴细胞数目改变能够帮助早期脓毒血症的诊断以及预后。

Objective： To investigate the changes of CD3^＋, CD4^＋ and CD8^＋ T-lymphocyte subset in patients with sepsis. Methods： We performed an electronic search of the Medline, PubMed, SPINGER, John Wiley, Science Direct, EBSCO, CNKI and WANFANG data to identify relevant studies. Data collected were extracted according to inclusion and exclusion criteria by two independent researchers. Then the quality of data was evaluated, and a meta-analysis was conducted using Revman5.3 software. Results： The CD3^＋, CD4^＋ and CD8^＋ T-lymphocyte subset in patients with sepsis was lower than the health control group, the differences were statistically significant （P〈0.05）; the CD3^＋, CD4^＋ and CD8^＋ T-lymphocyte subset in patients with sepsis of death group was lower than patients with sepsis of survival group, the differences were statistically significant （P〈0.05）. Conclusion： The early changes of CD3^＋, CD4^＋ and CD8^＋ T-lymphocyte subset in patients with sepsis help early diagnosis and prognosis.