肠道微生物与肝硬化及其并发症的研究进展

The relation between gut microbiota and liver cirrhosis and its complications:Research progress

人体肠道中数量可观、种类丰富的微生物对于维持人体健康起到重要作用。大量研究表明肠道微生物对肝硬化及其并发症有重要影响。当机体内外环境改变时会引起肠道微生物的变化,影响肝硬化及其并发症的发生和发展,而肝硬化及其并发症的发生发展也会引起肠道微生物的紊乱,二者相互联系,相互影响。通过对肠道微生物的检测和调节有助于肝硬化及其并发症的诊断与治疗。本文就肠道微生物与肝硬化及其并发症关系的研究现状,以肠道微生物为靶标的诊断治疗肝硬化及其并发症的策略以及现存在的问题进行综述。

There is a great number of and many kinds of bacteria in the human gut,which plays an important role in human health.Several studies have showed that liver cirrhosis and its complications are related to gut microbiota.When the internal and external environment of the body changes and there is gut microbiota imbalance,cirrhosis and its complications may develop.The existence of cirrhosis and its complications can cause or aggravate intestinal flora imbalance.The status of the body′s gut microbiota is closely related to cirrhosis and its complications,and they can influence each other.The detection and regulation of intestinal microbiota could help the diagnosis and treatment of liver cirrhosis and its complications.This review mainly discusses the relationship between alterations in intestinal flora and cirrhosis and its complications,the diagnosis and treatment targeting gut microbiota,as well as the existing problems.