胃乃安胶囊联合奥美拉唑治疗十二指肠溃疡的临床研究

Clinical study on Weinaian Capsuls combined with omeprazole in treatment of duodenal ulcer

目的探讨胃乃安胶囊联合奥美拉唑治疗十二指肠溃疡的临床疗效。方法收集2016年1月—2017年1月在中国人民解放军第一八八医院接受治疗的十二指肠溃疡患者76例,随机分为对照组(38例)和治疗组(38例)。对照组患者口服奥美拉唑肠溶胶囊,20 mg/次,1次/d。治疗组在对照组的基础上口服胃乃安胶囊,4粒/次,3次/d。两组患者均治疗4周。评价治疗后两组患者临床疗效,比较治疗前后两组临床症状消失时间、血清细胞性因子和血清胃肠激素水平变化。结果治疗后,对照组总有效率为81.58%,显著低于治疗组的97.37%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组溃疡痛、烧心、反酸消失时间均比对照组明显缩短,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清IL-8、肿瘤坏死因子-α(TNF-α)、高迁移率蛋白族1(HMGB1)水平均明显低于同组治疗前(P<0.05);且治疗组上述血清细胞性因子水平明显低于对照组(P<0.05)。治疗后,两组患者血清肾上腺髓质素(AM)、胃肠激素胃泌素(GAS)水平明显降低,降钙素基因相关肽(CGRP)和生长抑素(SS)水平明显升高,同组比较差异具有统计学意义(P<0.05);且治疗组上述血清胃肠激素指标水平明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论胃乃安胶囊联合奥美拉唑治疗十二指肠溃疡的临床效果明确,可明显降低血清炎性因子及胃肠激素水平,具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Weinaian Capsuls combined with omeprazole in treatment of duodenal ulcer. Methods Patients（76 cases） with duodenal ulcer in No.188 Hospital of PLA from January 2016 to January 2017 were randomly divided into control（38 cases） and treatment（38 cases） groups. Patients in the control group were po administered with Omperazole Enteric-coated Capsules, 20 mg/time, once daily. Patients in the treatment group were po administered with Weinaian Capsuls on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, clinical efficacy was evaluated, and the disappearance time of clinical symptom, the changes of serum cytokine and serum gastrointestinal hormones levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.58%, which was significantly lower than 97.37% in the treatment group, and there were differences between two groups（P〈0.05）. After treatment, the clinical symptom disappearance time of ulcer pain, heartburn, acid reflux in the treatment group was significantly shorter than that in the control group, with significant difference between two groups（P〈0.05）. After treatment, the IL-8, TNF-α and HMGB1 levels in two groups were significantly decreased（P〈0.05）. And the serum cytokine levels in the treatment group was significantly lower than those in the control group（P〈0.05）. After treatment, the AM and GAS levels in two groups were significantly decreased, but CGRP and SS levels were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. And the gastrointestinal hormones levels in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Weinaian Capsuls combined with omeprazole has clear clinical effect in treatment of duodenal ulcer, can significantly reduce the serum inflammatory factors and gastrointestinal hormones levels, which has a certain clinical application value.