摘要
It has been well-established that blood biomolecules deposit on the surface of nanoparticles forming a protein rich layer,known as‘‘protein corona',which directly interacts with and is recognized by cells.These interactions play a critical role in affecting nanoparticle biological properties,including biodistribution[1],pathophysiology[2],and therapeutic efficacy[3].The compositions of protein corona undergo dynamic exchange in vivo and are
It has been well-established that blood biomolecules deposit on the surface of nanoparticles forming a protein rich layer, known as ＂protein corona＂, which directly interacts with and is recognized by cells. These interactions play a critical role in affecting nanopar- ticle biological properties, including biodistribution [1], patho- physiology [2], and therapeutic efficacy [3].
基金
supported by the National Basic Research Program of China(2016YFA0201600)
the Chinese Academy of Sciences Key Research Program for Frontier Sciences(QYZDJ-SSSLH022),the Chinese Academy of Sciences Interdisciplinary Innovation Team
the National Science Fund for Distinguished Young Scholars(11425520)
