期刊文献+

程序性死亡配体1在三阴性乳腺癌中的研究进展 被引量:5

原文传递
导出
摘要 乳腺癌是女性常见的恶性肿瘤,三阴性乳腺癌(TNBC)侵袭性强,转移率高,预后差。程序性死亡配体1(PDL1)在介导肿瘤细胞免疫逃逸中起着重要作用,其在TNBC中的研究也不断深入。笔者对TNBC中PDL1的表达、调控、治疗等方面的研究进展作一综述,以期为TNBC的治疗提供新的思路。
出处 《中华乳腺病杂志(电子版)》 CAS CSCD 2017年第4期234-237,共4页 Chinese Journal of Breast Disease(Electronic Edition)
基金 国家自然科学基金面上项目(81472575 81472469)
  • 相关文献

参考文献1

二级参考文献29

  • 1BRONTE V,MOCELLIN S.Suppressive influences in the immune response to cancer[J].J Immunother,2009,32(1):1-11.
  • 2YANG L,PANG Y,MOSES H-L.TGF-b and immune cells:an important regulatory axis in the tumor microenvironment and progression[J].Trends Immunol,2010,31(6):220-227.
  • 3NOMURA T,SAKAGUCHI S.Naturally arising CD25+CD4+ regulatory T cells in tumor immunity[J].Curr Top Microbiol Immunol,2005,293:287-302.
  • 4CHALMIN F,LADOIRE S,MIGNOT G,et al.Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosup-pressive function of mouse and human myeloid-derived suppressor cells[J].J Clin Invest,2010,120(2):457-471.
  • 5LIU Z,KIM J H,FALO L D,Jr,et al.Tumor regulatory T cells potently abrogate antitumor immunity[J].J Immunol,2009,182(10):6160-6167.
  • 6WYSOCKI P J,KAZIMIERCZAK U,SUCHORSKA W,et al.Gene-modified tumor vaccine secreting a designer cytokine Hyper-Interleukin-6 is an effective therapy in mice bearing orthotopic renal cell cancer[J].Cancer Gene Ther,2010,17(7):465-475.
  • 7ANTONIA S J,SEIGNE J,DIAZ J,et al.Phase I trial of a B7-1 (CD80) gene modified autologous tumor cell vaccine in combination with systemic interleukin-2 in patients with metastatic renal cell carcinoma[J].J Urol,2002,167(5):1995-2000.
  • 8NEMUNAITIS J.GVAX (GMCSF gene modified tumor vaccine) in advanced stage non small cell lung cancer[J].J Control Release,2003,91(1-2):225-231.
  • 9HU H M,URBA W J,FOX B A.Gene-modified tumor vaccine with therapeutic potential shifts tumor-specific T cell response from a type 2 to a type 1 cytokine profile[J].J Immunol,1998,161(6):3033-3041.
  • 10BUCHNER A,POHLA H,WILLIMSKY G,et al.Phase 1 trial of allogeneic gene-modified tumor cell vaccine RCC-26/CD80/IL-2 in patients with metastatic renal cell carcinoma[J].Hum Gene Ther,2010,21(3):285-297.

共引文献21

同被引文献34

引证文献5

二级引证文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部