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Screening novel stress granule regulators From a natural compound library 被引量:1

Screening novel stress granule regulators From a natural compound library
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摘要 Dear Editor Modulation of mRNA transportation, localization, translational efficiency, and degradation plays an important role in the regulation of gene expression. In eukaryotic cells, translationally repressed mRNAs may be recruited into distinct intracellular foci termed as RNA granules, which are microscopically visible non-membrane-bound organelles composed of messenger ribonucleoproteins (mRNPs) (Anderson and Kedersha, 2009). Dear Editor Modulation of mRNA transportation, localization, translational efficiency, and degradation plays an important role in the regulation of gene expression. In eukaryotic cells, translationally repressed mRNAs may be recruited into distinct intracellular foci termed as RNA granules, which are microscopically visible non-membrane-bound organelles composed of messenger ribonucleoproteins (mRNPs) (Anderson and Kedersha, 2009).
机构地区 Tsinghua Univ
出处 《Protein & Cell》 SCIE CAS CSCD 2017年第8期618-622,共5页 蛋白质与细胞(英文版)
基金 This study was supported by funds from the China Postdoctoral Science Foundation (No. 158358) and State Key Laboratory of Membrane Biology (to Y.-B, Yan). Dr. X.-J. Chen was supported by the Excellent Postdoctoral fellowship from the Tsinghua-Peking Joint Center for Life Sciences.
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