注射用益气复脉联合西医疗法治疗心力衰竭临床观察

Clinical Observation of Yiqi Fumai Injection Combined with Western Medicine for Heart Failure

目的 :观察注射用益气复脉联合西医疗法治疗心力衰竭患者的临床疗效。方法 :将90例心力衰竭气阴两虚证患者随机分为研究组与对照组各45例,2组均以常规疗法治疗,研究组给予注射用益气复脉联合盐酸多巴酚丁胺注射液治疗,对照组给予盐酸多巴酚丁胺注射液治疗,以7天为1疗程,观察2疗程。治疗前后测定患者的血浆N末端B型钠尿肽前体(NT-pro BNP)水平,经心脏彩超测定左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)、左室射血分数(LVEF)、舒张早期二尖瓣血流速度(E)、舒张晚期二尖瓣血流速度(A),并计算E/A比值;统计治疗前后的心功能分级情况,评价临床疗效,观察不良反应发生情况。结果:治疗后,研究组总有效率为93.33%,对照组总有效率为73.33%,2组比较,差异有统计学意义(P<0.05)。2组NT-pro BNP及各项心功能指标值均较治疗前改善(P<0.05),研究组各项指标改善情况均优于对照组(P<0.05)。2组心功能情况均较治疗前改善(P<0.05),研究组心功能改善情况优于对照组(P<0.05)。2组患者均未发生不良反应情况。结论:注射用益气复脉联合西医疗法治疗心力衰竭气阴两虚证可有效改善患者的心力衰竭严重程度及心功能,安全性好。

Objective. To observe the clinical effect of Yiqi Fumai injection combined with western medicine for Heart failure. Methods： Selected 90 heart failure patients with Qi-Yin deficiency syndrome and divided them into the study group and the control group being 45 cases in each randomly. The two groups were both given routine treatment, and the control group was given dobutamine hydrochloride injection while the study group was given Yiqi Fumai injection combined with dobutamine hydrochloride injection. One course lasted for seven days. Observation lasted for two courses. Detected level of plasma N-terminal pro-B-type natriuretic peptide （NT-pro BNP） of patients before and after treatment, and detected left ventricular end systolic diameter（LVESD）, left ventricular enddiastolic diameter（LVEDD）, left ventricular ejection fraction（LVEF）, mitral flow velocity of early diastole （E）, mitral flow velocity of late diastole （A） with echocardiography and calculated E/A; recorded classification of cardiac function and clinical effect before and after treatment; observed incidence of adverse reaction. Results- After treatment, the total effective rate was 93.33% and 73.33% in the study group and the control group respectively, difference being significant （P〈 0.05）. NT-pro BNP and every cardiac function index of the two groups were improved （P〈 0.05）, and the improvement of the study group was better（P〈 0.05）. Cardiac function of the two groups were improved （P〈 0.05）, and the improvement of the study group was better（P 〈 0.05）. There was no adverse reaction in the two groups. Conclusion： Yiqi Fumai injection combined with western medicine can improve cardiac function of heart failure patients with Qi-Yin deficiency syndrome significantly, which has good security.