新疆乌鲁木齐市某附属医院维吾尔族就诊患者高尿酸血症与肾脏功能的相关性研究

Correlation between hyperuricemia and renal function among Uygur patients in an affiliated hospital of Urumqi in Xinjiang

目的为了解新疆乌鲁木齐市维吾尔族人群中高尿酸血症组与正常组血尿酸、血脂及其肾功能生化指标的差异。方法采用病例对照研究方法,调查乌鲁木齐市某附属医院就诊的维吾尔族高尿酸血症患者986名,同期体检者1 353名,年龄平均为20~80岁,对两组人群进行问卷调查,体格检查和血生化检测,统计并分析维吾尔族人群血尿酸值及其他生化指标。结果维吾尔族人群中高尿酸血症组血尿酸值平均为(473.01±88.11)μmol/L,对照组血尿酸值的平均为(259.43±78.46)μmol/L,病例组体质指数(BMI)、腰臀比、收缩压、舒张压、尿素氮、肌酐、甘油三脂和总胆固醇均高于对照组,差异有统计学意义(均P<0.05)。高尿酸血症组与对照组在代谢性指标(肥胖、高血压、高甘油三酯和高胆固醇)上差异均有统计学意义(均P<0.05)。结论乌鲁木齐市维吾尔族人群中高尿酸血症患者在相关指标及代谢性指标上均高于正常组(肾小球滤过率除外),其中年龄、尿素氮和肌酐可能是高尿酸血症发生肾功能损伤(CKD)的危险因素。

[Objective] To know the differences in serum uric acid, blood lipids and biochemical indicators of renal function between hyperuricemia group and normal group among Uygur people receiving the physical examination in Urumqi of Xinjiang. [Methods] With the method of case-control study, 986 Uygur patients with hyperuricemia and 1 354 people receiving the physical examination over the same period in Urumqi of Xinjiang were investigated, which the average age was 20-80 years old. Two groups were given the questionnaire survey, physical examination and blood biochemical detection, to analyze the blood uric acid value and other biochemical indicators of Uygur population. [Results] The average value of blood uric acid in Uygur hyperuricemia group and normal group was （473.01±88.11 ） μmol/L and （259.43±78.46） μmol/L respectively. The values of BMI, waist to hip ratio, systolic pressure, diastolic blood pressure, urea nitrogen, creatinine, triglycerides and total cholesterol in normal group were higher than those in hyperuricemia group, and the differences were statistically significant （P〈0.05）. There were statistically significant differences in metabolic indexes （obesity, high blood pressure, high triglyeerides and high cholesterol） between hyperuricemia group and normal group（P〈0.05）. [ConclusionJ The levels of indexes related to hyperuricemia and metabolic indexes （with the exception of glomerular filtration rate） among Uygur hyperuricemia patients in Urumqi are higher than those in normal group. Age, urea nitrogen and creatinine may be the risk factors for chronic kidney disease in hyperuricemia patients..