下颌骨骨折术后感染相关因素分析

Analysis of relative factors associated with postoperative infection of mandibular fractures

目的:探讨下颌骨骨折行坚固内固定术后与感染相关的危险因素。方法:设计病例对照研究,收集我院2009年1月—2015年12月期间下颌骨骨折坚固内固定手术患者447例,其中出现术后感染的病例为26例(实验组)。从每例发生术后感染的患者入院前2周内,随机选取1例下颌骨骨折坚强内固定术后无任何并发症的患者纳入对照组,共26例。收集整理相关的变量数据,采用SAS9.2软件包在2组间行二变量和多因素Logistic回归分析,确定与术后感染相关的因素。结果:回归分析结果显示,增长的下颌骨骨折严重程度评分(OR=2.509,95% CI为1.083~5.814)以及患者欠佳的全身健康状态(OR=5.019,95% CI为1.294~19.472)是导致术后感染的相关危险因素。在二变量检验中,抗生素使用天数与术后感染具有相关性(P<0.05)。结论:骨折的严重程度和患者欠佳的身体健康状态是下颌骨骨折术后感染的危险因素。

PURPOSE： To explore risk factors associated with postoperative inflammatory complications （POIC） after rigid internal fixation of mandibular fractures. METHODS： A case-control study was designed and a sample of 447 patients treated with rigid internal fixation for mandibular fractures were selected from January 2009 to December 2015.26 patients developed POIC after treatment were categorized into the experimental group. Twenty-six cases with no complications were enrolled into the control group. Data were collected and bivariate and multiple logistic analyses were used to identify factors associated with POIC between the two groups by SAS9.2 software package. RESULTS： In multiple regression model, an increasing Mandibular Injury Severity Score （0R=2.509; 95%CI 1.083-5.814） and health condition below the baseline （0R=5.019; 95%CI 1.294-19.472） were significantly （P〈0.05） associated with an increased risk for a POIC. However, in bivariate analyses, the use of antibiotics was associated with POIC （P〈0.05）. CONCLUSIONS： Postoperative inflammatory complications are associated with the Mandibular Injury Severity and health condition of the patients.