核因子κB受体活化因子配体在牙源性角化囊性瘤开窗减压前、后的表达

Expression of receptor activator of nuclear factor-κB ligand in keratocystic odontogenic tumor before and after decompression

目的:观察核因子κB受体活化因子配体(RANKL)在牙源性角化囊性瘤(KOCT)开窗减压前、后的表达,探讨开窗减压治疗KCOT的可能机制。方法:收集22例经病理证实为KCOT的患者开窗减压治疗前、后的标本,进行RANKL免疫组织化学染色,采用SPSS17.0软件包对数据进行配对t检验。结果:22例KCOT开窗减压前衬里上皮中均有RANKL的阳性表达,开窗减压后RANKL表达水平下降,开窗前、后的RANKL表达有显著差异(P<0.05)。结论:RANKL在KCOT囊壁上皮中呈高表达,开窗减压后表达水平降低,可促进囊壁衬里上皮向正常口腔黏膜上皮转化。

PURPOSE： To investigate the expression of receptor activator of nuclear factor-κB ligand （RANKL） in keratocystic odontogenic tumor （KCOT） before and after decompression. METHODS： Twenty two pairs of paraffin- embeded tissue specimens of KCOT were collected and subjected to immunohistochemical analysis of RANKL.The data were analyzed with SPSS17.0 software package for paired t test. RESULTS： RANKL positive cells were observed in the preoperative KCOT epithelium. The expression of RANKL was down-regulated after decompression （P 〈0.05）. CONCLUSIONS： Decrease of RANKL expression after decompression may facilitate the lining epithelium of KCOT transforming to normal oral mucosal epithelium.