宫颈癌患者梅毒感染情况和血液学相关指标特征分析

Anylsis on syphilis infection status and characteristics of hematology-related indicators in cervical cancer patients

目的探讨宫颈癌患者的梅毒感染情况和血液学相关指标的特征分析。方法将2014年9月-2016年10月在该院就诊的宫颈癌及癌前病变患者116例分为宫颈癌组和癌前病变组,每组各58例;另选取同期在该院体检的健康女性75例作为对照组。采用梅毒螺旋体明胶颗粒凝集试验检测3组患者的梅毒感染情况,并检测血液中常规指标中性粒细胞/淋巴细胞比率(NLR)、纤维蛋白原(FIB)、单核细胞、血红蛋白(Hb)及血清白蛋白(ALB)。结果宫颈癌组梅毒感染例数为13例(22.41%),癌前病变组梅毒感染例数为5例(8.62%),两组相比,差异有统计学意义(P<0.05);对照组梅毒感染例数为1例(1.33%),与癌前病变组相比,差异有统计学意义(P<0.05);与癌前病变组相比,宫颈癌组的NLR和FIB均显著上升(均P<0.05);与对照组相比,癌前病变组的NLR和FIB均显著上升(均P<0.05);与癌前病变组相比,宫颈癌组的单核细胞和Hb均显著减少(均P<0.05);与对照组相比,癌前病变组的单核细胞和Hb均显著减少(均P<0.05)。结论宫颈癌患者梅毒感染率较高,同时伴有炎症反应、血液高凝、免疫力低下、营养失衡等现象,因此应密切关注梅毒抗体及血常规的变化。

Objective To explore syphilis infection status and characteristics of hematology-related indicators in cervical cancer patients. Methods A total of 116 patients diagnosed as cervical cancer and cervical precancerous lesion in the hospital from September 2014 to October 2016 were selected and divided into cervical cancer group and cervical precancerous lesion group,58 patients in each group. Seventy-five healthy women receiving physical examination in the hospital during the same period were selected as control group. Treponema pallidum gelatin particles agglutinate experiment was used to detect syphilis infection situations in the three groups. Neutrophil/lymphocyte ratio（ NLR）,fibrinogen（ FIB）,monocyte,hemoglobin（ Hb）,and serum albumin were detected. Results The rates of syphilis infection in cervical cancer group and cervical precancerous lesion group were 22. 41%（ 13 patients） and 8. 62%（ 5 patients）,respectively,there was statistically significant difference between the two groups（ P〈0. 05）; the rate of syphilis infection in control group was 1. 33%（ one patient）,compared with cervical precancerous lesion group,there was statistically significant difference（ P〈0. 05）; compared with cervical precancerous lesion group,NLR and FIB in cervical cancer group increased significantly（ all P〈0. 05）; compared with control group,NLR and FIB in cervical precancerous lesion group increased significantly（ all P〈0. 05）; compared with cervical precancerous lesion group,monocytes and Hb in cervical cancer group decreased significantly（ all P〈0. 05）; compared with control group,monocytes and Hb in cervical precancerous lesion group decreased significantly（ all P〈0. 05）. Conclusion The infection rate of syphilis in cervical cancer patients is high,accompanied by the phenomenons of inflammatory response,high blood coagulation state,hypoimmunity,and nutritional imbalance,so the clinicians should pay close attention to changes of syphilis antibody and blood routine test.