人附睾蛋白4联合CA199、CA724检测诊断卵巢癌的价值

Value of joint detection of human epididymis protein 4 combined with CA199 and CA724 in diagnosis of ovarian cancer

目的探讨人附睾蛋白4(HE4)联合糖类抗原199(CA199)及糖类抗原724(CA724)血清检测在卵巢癌患者中的诊断价值。方法以该院妇科2015年6月-2016年10月收治的卵巢癌患者86例(卵巢癌组)及卵巢良性疾病患者120例(卵巢良性组)为研究对象,同时以同期120例前来体检的健康女性为对照(健康对照组)。所有对象均采集静脉血,根据试剂盒说明进行HE4、CA199以及CA724水平检测,比较分析各组间检测结果。结果卵巢癌组患者HE4、CA199以及CA724血清水平和阳性率分别为[(103.8±13.9)pmol/L,76.74%]、[(125.5±24.9)U/ml,48.84%]、[(44.7±14.6)U/ml,47.67%]均显著高于卵巢良性组[(57.2±9.28)pmol/L,5.83%]、[(32.2±14.5)U/ml,20.83%]、[(11.1±5.7)U/ml,15.00%],健康对照组[(36.8±8.6)pmol/L,2.50%]、[(27.9±10.3)U/ml,5.83%]、[(9.6±3.1)U/ml,3.33%],差异均有统计学意义(F=6.457、7.582、6.432;χ~2=0.965、0.658、0.747,均P<0.05);卵巢癌组3项指标联合检测的敏感度(87.21%)显著高于各单项指标(76.74%、48.84%、47.67%),差异有统计学意义(χ~2=0.758,P<0.05)。结论 (1)血清HE4、CA199以及CA724的表达均与卵巢癌有着密切关系,在卵巢癌诊断中具有重要价值;(2)3项指标联合检测的敏感度显著高于各单项指标检测,3项联合检测在卵巢癌检测中具有很高的临床价值。

Objective To explore the clinical value of joint detection of serum human epididymis protein 4（ HE4） combined with CA199 and CA724 in diagnosis of ovarian cancer patients. Methods Eighty-six patients with ovarian cancer（ ovarian cancer group） and120 patients with benign ovarian diseases（ benign group） treated in Department of Gynecology in the hospital from June 2015 to October2016 were selected as study objects. A total of 120 healthy women receiving physical examination in the hospital during the same period were chosen as healthy control group. Venous blood samples of all the subjects were collected,according to the kit instructions,HE4,CA199 and CA724 levels were detected,the results among different groups were comparatively analyzed. Results The levels and positive rates of serum HE4,CA199,CA724 in ovarian cancer group were [（ 103. 8 ± 13. 9） pmol/L,76. 74%], [（ 125. 5 ± 24. 9） U/ml,48. 84%],and[（ 44. 7±14. 6） U/ml,47. 67%],respectively,which were statistically significantly higher than those in benign group [（ 57. 2±9. 28）pmol/L,5. 83%;（ 32. 2± 14. 5） U/ml,20. 83%;（ 11. 1 ± 5. 7） U/ml,15. 00%] and healthy control group [（ 36. 8 ± 8. 6） pmol/L,2. 50%;（ 27. 9±10. 3） U/ml,5. 83%;（ 9. 6±3. 1） U/ml,3. 33%]（ F = 6. 457,7. 582,6. 432; χ~2= 0. 965,0. 658,0. 747,P〈0. 05）.The sensitivity of combined detection of the three indexes（ 87. 21%） in ovarian cancer group was statistically significantly higher than those of single detection of each index（ 76. 74%,48. 84%,47. 67%）（ χ~2= 0. 758,P〈0. 05）. Conclusion The expression levels of serum HE4,CA199 and CA724 are closely related to ovarian cancer,which are of great value in diagnosis of ovarian cancer; the sensitivity of combined detection of the 3 indexes is significantly higher than those of single detection of each index,combined detection method has a high clinical value in detection of ovarian cancer.