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蜂胶类黄酮对肺结核合并糖尿病的辅助治疗作用探讨 被引量:4

Auxiliary therapeutic effect of propolis flavonoid on pulmonary tuberculosis complicated by diabetes mellitus
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摘要 目的探讨蜂胶类黄酮对肺结核合并糖尿病(PTB-DM)患者的辅助治疗作用及其免疫调节机制,为寻求安全有效的PTB-DM防治措施提供参考。方法以PTB-DM患者120人为对象,利用随机数字表随机分为A、B、C三组,每组40人,A、B组分别按1 000、2 000 mg/d剂量口服含蜂胶类黄酮的蜂胶软胶囊,C组口服不含蜂胶类黄酮的蜂胶基质软胶囊作为对照,观察6个月,比较各组疗效差异、试验前后WBC及分类、T淋巴细胞亚群CD3^+、CD4^+、CD8^+、CD4^+/CD8^+比值的差异。结果三组有效率差异有统计学意义(P=0.005),其中B组为94.6%、A组为76.9%、C组为64.1%;细胞免疫7项指标差异有统计学意义(P=0.000),其中WBC计数、中性粒细胞百分比为B组高于A与C组,淋巴细胞百分比为B组最高、A组其次、C组最低;T淋巴细胞:CD3^+、CD4^+为B组>A组>C组,CD8^+的组间差异无统计学意义(P>0.05),CD4^+/CD8^+比值为A与B组高于C组。结论蜂胶类黄酮对PTB-DM患者具有辅助治疗作用,可改善WBC及分类、T淋巴细胞亚群CD3^+、CD4^+、CD4^+/CD8^+比值等指标,增强细胞免疫水平具有作用,且有剂量差异。 Objective To explore the auxiliary therapeutic effect and immune regulating mechanism of propolis flavonoid in patients with pulmonary tuberculosis complicated by diabetes mellitus (PTB-DM), and to provide references for seeking safe and effective PTB-DM prevention and control measures. Methods One hundred and twenty PTB-DM patients served as the objects, and were randomly divided into group A, group B and group C (each n=40) by the random digital table. The patients in group A and group B were assigned to take 1,000 mg/d and 2,000 mg/d propolis flavonoid soft capsule respectively. The patients in group C served as controls and received propolis soft capsule without flavonoid. After 6 months, the differences in curative effects, WBC count and classification, the levels of T lymphocyte subsets CD3+, CD4+, CD8+ and the ratio of CD4+/CD8+ before and after the test were compared among the groups. Results The effective rates in group B, group A and group C were 94.6%, 76.9% and 64.1% respectively, showing statistically significant differences (P=0.005). The 7 indexes of cellular immune function exhibited statistically significant differences (P=0.000), of which WBC count and neutrophil percentage were higher in group B than in the group A and group C, and lymphocyte percentage and the levels of CD3+ and CD4+ were the highest in group B, followed by group A and group C. No statistically significant difference was found in the level of CD8+ among the three groups (P〉0.05). The ratio of CD4+/CD8+ was higher in group A and B than in group C. Conclusions Propolis flavonoid has auxiliary therapy effect in PTB-DM patients, and can improve WBC count and classification, the levels of T lymphocyte subsets CD3+, CD4+ and the ratio of CD4+/CD8+. It enhances cellular immunity in a dose-dependent manner.
出处 《实用预防医学》 CAS 2017年第9期1037-1039,1047,共4页 Practical Preventive Medicine
基金 湖南省自然科学基金项目(14JJ2112)
关键词 蜂胶类黄酮 肺结核合并糖尿病 白细胞 T淋巴细胞亚群 细胞免疫 propolis flavonoid pulmonary tuberculosis complicated by diabetes mellitus WBC T lymphocyte subset cellular immunity
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