侵袭性肺腺癌微乳头亚型与淋巴结转移的相关性分析

Correlation analysis of invasive pulmonary adenocarcinoma micropapillary subtype and lymph node metastasis

目的探讨侵袭性肺腺癌中微乳头亚型与淋巴结转移的相关性。方法术后病理检查证实为侵袭性肺腺癌的标本433例,依据IASLC/ATS/ERS分类标准进行病理阅片并确定病理亚型,记录患者的年龄、性别、是否吸烟、肿瘤直径、淋巴结转移、肿瘤分期等信息。结果 433例肺腺癌患者,包含微乳头亚型成分92例,占所有侵袭性肺腺癌的21.2%。包含微乳头亚型成分患者发生淋巴结转移率为43.4%,远高于不包含微乳头亚型组11.7%的淋巴结转移率,两组比较差异有统计学意义(P<0.05)。结论在肺腺癌中微乳头病理亚型与淋巴结转移有关,提示预后不良。

Objective To determine correlation of invasive pulmonary adenocarcinoma micropapillary subtype and lymph node metastasis. Methods 433 cases were confirmed with invasive pulmonary adenocarcinoma through postoperative pathological examination. According to the classification criteria of IASLC/ATS/ERS,the pathological subtype was determined. Recording the patients ＇age,sex,smoking,tumor diameter,lymph node metastasis,tumor staging and so on. Results Micropapillary subtype were identified in 92 patients（ 21. 2%）. Patients with micropapillary subtype had a significantly higher incidence of pathologic lymph node metastasis,compared with patients without micropapillary subtype（ 43. 4%vs. 11. 7%,P〈0. 05）. Conclusion Micropapillary positive adenocarcinomas resulted in negative impact on postoperative prognosis among pulmonary adenocarcinomas. Pulmonary adenocarcinoma with a micropapillary subtype should be considered as poor prognosis factor.