一种青钱柳叶组方对糖尿病模型大鼠的治疗作用

Treatment effects of the QQ-1 prescription on diabetes model rats

目的研究一种青钱柳叶组方(QQ-1)对糖尿病模型大鼠的治疗作用,为其开发提供实验依据。方法以高脂饲料合并链脲佐菌素(STZ)诱导糖尿病大鼠模型,选取50只造模成功的大鼠分为5组,连续6周分别给予蒸馏水、青钱柳叶组方低、中、高剂量[58.5、117、234 mg(/kg·d)]和吡格列酮口服,观察青钱柳叶组方对模型大鼠的体重、血糖值、胰岛素含量、糖化血红蛋白含量、糖耐量、胰岛组织的影响。结果连续6周口服给予青钱柳叶组方后,与模型组比较,青钱柳叶组方中剂量组、青钱柳叶组方高剂量组的体重增加,血糖分别下降至(17.22±2.46)和(16.85±1.93)mmol/L,血清胰岛素含量升高至(11.55±2.58)和(12.55±1.96)mmol/L,糖化血红蛋白含量降低至(7.67±1.54)和(7.38±1.34)g/m L,血糖曲线下面积减少至(33.69±6.33)和(29.74±5.80),胰岛组织损伤减轻。吡格列酮组糖尿病各项指标均有明显改善。结论青钱柳叶组方可促进糖尿病大鼠的胰岛素分泌,降低血糖值及糖化血红蛋白的含量,改善糖耐量受损,减轻胰岛β细胞的损伤,具有良好的开发前景。

Objective Investigate the treatment effects of health product Qingqian-1 （QQ-1） on diabetes model rats for the further development. Methods Before received QQ-1 （58.5, 117,234 mg/（kg, d） ） and pioglitazone orally for 6 weeks, the diabetes model rats were induced by high-fat diet plus streptozotocin （STZ）. Meanwhile, the treatment effects of QQ-1 on those diabetes model rats were evaluated with the body weights, levels of blood glucose, insulin and glycosylated hemoglobin, glucose tolerance, and pathological changes of pancreatic islands. Results After a 6-week treatment, compared with the model group, QQ-1 117 mg/（kg, d） group and 234 mg/（kg·d） group were increased in the body weights, the blood glucose was reduced to （17.22±2.46） and （16.85±1.93）mmol/L, the serum insulin level was increased to （ 11.55±2.58 ） and （ 12.55±1.96 ） mmol/L, the glycosylated hemoglobin was reduced to （ 7.67±1.54） and （7.38±1.34） g/mL, the area under curve of blood glucose was reduced to （33.69±6.33） and （29.74±5.80）, respectively in QQ-1 117 mg/（kg·d） group and 234 mg/（kg·d） group. And the pathological changes of pancreatic islet were improved in corresponding groups. There was a significant improvement in the index of diabetes in pioglitazone group.Conclusion The health product QQ-1 could increase the secretion of insulin, improve the glucose tolerance, and reduce the blood glucose, the glycosylated hemoglobin and the damage of pancreatic panceatic.β-cells Thus, QQ-1 has a promising prospect.