阿昔洛韦联合泼尼松治疗带状疱疹的临床疗效观察

Clinical effect of acyclovir combined with prednisone in treatment of herpes zoster

目的 观察阿昔洛韦联合泼尼松治疗带状疱疹的临床疗效.方法 选取 128例带状疱疹患者作为研究对象,采用完全随机分配法分为治疗组和对照组,每组各64例.治疗组口服阿昔洛韦与泼尼松,对照组单纯口服阿昔洛韦.观察两组的临床疗效.结果 治疗组止疱、结痂及痊愈时间,与对照组相比,差异无统计学意义（t=1.76、1.79、1.41,均P＞0.05）,而治疗组止痛时间（3.2±1.2）d,明显少于对照组的（7.4±2.6）d（t=11.73,P＜0.01）.治疗组总有效率95.3％,明显高于对照组的73.4％,差异有统计学意义（χ2=16.13,P＜0.01）.治疗组出现2例后遗神经痛,对照组出现8例后遗神经痛,治疗组不良反应发生率明显低于对照组（χ2=6.01,P＜0.05）.结论 阿昔洛韦联合泼尼松治疗带状疱疹患者疗效显著,缩短疼痛时间,减少后遗神经痛的发生,值得临床推广应用.

Objective To observe the clinical efficacy of acyclovir combined with prednisone in the treatment of herpes zoster.Methods 128 patients with herpes zoster were selected as study objects,and they were divided into the treatment group and the control group by using the method of complete random distribution,64 cases in each group.The patients in the treatment group were treated with oral acyclovir and prednisone,while those in the control group received oral acyclovir alone.The clinical efficacy of the two groups was observed.Results The blistering,crusting and healing time had no significant differences between the two groups（t=1.76,1.79,1.41,all P〉0.05）.The analgesic time of the treatment group was （3.2±1.2）d,which was significantly shorter than （7.4±2.6）d of the control group （t=11.73,P〈0.01）.The total effective rate of the treatment group was 95.3%,which was significantly higher than 73.4% of the control group,the difference was significant（χ2=16.13,P〈0.01）.In the treatment group,there were 2 cases of postherpetic neuralgia.In the control group,8 cases had postherpetic neuralgia.The incidence rate of adverse events in the treatment group was significantly lower than that in the control group（χ2=6.01,P〈0.05）.Conclusion Acyclovir combined with prednisone in the treatment of herpes zoster has significant clinical efficacy,it can shorten the analgesic time,and is worthy of clinical application.