吉西他滨联合卡培他滨治疗转移性三阴乳腺癌45例临床观察

Clinical Observation of Gemcitabine Combined with Capecitabine for Treating Metastatic Triple-Negative Breast Cancer in 45 Cases

目的观察吉西他滨联合卡培他滨治疗转移性三阴乳腺癌(TNBC)的临床疗效。方法将2015年1月至2016年3月收治的90例转移性TNBC患者随机分为两组,各45例,对照组患者静脉滴注多西他赛注射液治疗,观察组患者联合吉西他滨与卡培他滨进行治疗,比较两组患者的临床疗效及毒性反应。结果观察组总有效率为60.00%,高于对照组的37.78%(P<0.05);毒性反应发生率为22.22%,低于对照组的42.22%(P<0.05)。结论吉西他滨联合卡培他滨治疗转移性TNBC的疗效确切,值得临床推广。

Objective To observe the clinical efficacy of gemcitabine combined with capecitabine in the treatment of metastatic triple-negative breast cancer（TNBC）.Methods Totally 90 patients with metastatic TNBC in our hospital from January 2015 to March 2016 were divided into two groups,45 cases in each group.The control group was treated with intravenous injection of docetaxel,and the observation group was treated with gemcitabine combined with capecitabine.The clinical efficacy and toxicity were compared between the two groups.Results The total effective rate of the observation group was 60.00%,which was significantly higher than 37.78% of the control group（P 〈 0.05）.The incidence rate of toxicity was 22.22%,which was significantly lower than 42.22% of the control group（P 〈 0.05）.Conclusion Gemcitabine combined with capecitabine in the treatment of metastatic TNBC is effective,it is worthy of clinical promotion.