利奈唑胺治疗革兰阳性球菌重症感染的疗效和安全性评价

Efficacy and Safety of Linezolid in Treating Severe Infection of Gram Positive Coccus

目的观察利奈唑胺治疗革兰阳性球菌重症感染的疗效和安全性。方法选取医院2014年10月至2016年10月收治的革兰阳性球菌重症感染患者86例。采用单双号法分为观察组和对照组,各43例。对照组患者给予万古霉素治疗,观察组患者给予利奈唑胺治疗。结果观察组患者的药物起效时间、住院时间均较对照组短(P<0.05);革兰阳性球菌清除率为93.02%,明显高于对照组的72.09%(P<0.05);不良反应发生率为6.98%,低于对照组的23.26%(P<0.05)。结论利奈唑胺治疗革兰阳性球菌重症感染效果显著,安全性高,值得临床推广。

Objective To observe the efficacy and safety of linezolid in the treatment of severe infection of gram positive coccus.Methods Totally 86 patients with severe infection from gram positive coccus admitted to our hospital from October 2014 to October2016 were selected and divided into the observation group and the control group according to the odd and even number method,43 cases in each group.The control group was treated with vancomycin,and the observation group was treated with linezolid.Results The onset time and length of hospital stay in the observation group were shorter than those in the control group（P 〈 0.05）.The clearance rate of gram-positive coccus in the observation group was 93.02%,which was significantly higher than 72.09% in the control group（P 〈 0.05）.The incidence rate of adverse reactions in the observation group was 6.98%,which was lower than 23.26% in the control group（P 〈 0.05）.Conclusion The efficacy and safety of linezolid in the treatment of severe infection of gram positive coccus are good,it is worthy of clinical promotion.