摘要
纳豆激酶主要是由枯草芽孢杆菌(Bacillus subtilis)代谢产生的碱性丝氨酸蛋白酶,因其具有较强的溶栓能力而著称。与其他的大多溶栓剂相比,纳豆激酶具有安全性好、成本低、易吸收、副作用小等优点,因此可用于开发溶栓药物。该文对国内外纳豆激酶的溶栓功效、理化特性、发酵工艺、活性测定、纯化、改性和产品进行了综述,对其当前研究中的关键问题进行分析,并对未来纳豆激酶的研究方向进行了展望。
Nattokinase is a kind of alkaline serine proteinase mainly from Bacillus subtilis and is well known for its strong thrombolytic property. Compared with most of other thrombolytic agents, it has good safety, low cost, easy absorption, low side effects and other advantages, which could be developed as a promising agent for thrombosis therapy. In this paper, the thrombolytic efficacy, physicochemical properties, fermentation process, activity determination, purification, modification and products of nattokinase at home and abroad were reviewed. The key issues in the current research of nattokinase were analyzed, and the future research direction of nattokinase was also prospected.
作者
高泽鑫
何腊平
刘亚兵
高冰
李翠芹
刘涵玉
GAO Zexin HE Laping LIU Yabing GAO Bing LI Cuiqin LIU Hanyu(School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China Key Laboratory of Agricultural and Animal Products Store ＆ Processing of Guizhou Province, Guizhou UniversRy, Guiyang 550025, China College of Bioengineering and Food Science, Hubei University of Technology, Wuhan 430068, China School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, China)
出处
《中国酿造》
CAS
北大核心
2017年第8期11-15,共5页
China Brewing
基金
贵州省重大专项项目子项目(黔科合重大专项字([2015]6004-5号))
贵州省农业攻关项目(黔科合支撑([2016]2580号))
关键词
纳豆激酶
溶栓
理化特性
纯化
改性
nattokinase
thrombolysis
physicochemical properties
purification
modification
