氨磺必利联合奥氮平对精神分裂症患者认知功能的影响

Effect of amisulpride and olanzapine on cognitive function in schizophrenia

目的:研究氨磺必利联合奥氮平对精神分裂症患者认知功能的影响。方法:选择2014年3月—2015年12月精神分裂症患者94例,根据随机数字表法均分为两组。单一药物组采用奥氮平治疗,药物联合组采用氨磺必利联合奥氮平治疗。比较两组患者疾病治疗总有效率、治疗前后阳性和阴性症状量表(PANSS)总分、治疗前后患者认知功能和生存质量情况的差异。结果:药物联合组疾病治疗总有效率比单一药物组高,差异有统计学意义(P<0.05);治疗前两组PANSS总分相似,差异无统计学意义(P>0.05);治疗后药物联合组相较于单一药物组PANSS总分改善更显著,差异有统计学意义(P<0.05)。治疗前两组认知功能和生存质量情况相似,差异无统计学意义(P>0.05);治疗后药物联合组相较于单一药物组认知功能和生存质量情况改善更显著,差异有统计学意义(P<0.05)。结论:氨磺必利联合奥氮平治疗精神分裂症,可有效改善患者认知功能和临床症状,促进患者治疗后生存质量的改善,可减轻患者痛苦,对减轻其家庭和社会负担均有重大意义。

Objective： To study the effect of amisulpride and olanzapine on cognitive function in schizophrenia. Methods：All 94 cases of schizophrenia patients in our hospital from December to March 2014 were divided into two groups according to the random number table method. The single drug group were treated with olanzapine treatment,drug combination group was treated with amisulpride combined with olanzapine treatment. The total effective rate of two groups of patients were compared,the positive and negative symptom scale（ PANSS） scores before and after treatment,the differences in cognitive function and quality of life of patients before and after treatment. Results： The drug combined group therapy the total effective rate was significantly higher than the single drug group（ P〈0. 05）,two groups before treatment PANSS score（ P〉0. 05）. After the end of treatment combined with drug group compared with the single drug group PANSS scores improved more significantly（ P〈0. 05）. The cognitive function and quality of life were similar between the two groups before treatment（ P〉0. 05）. After the end of treatment,the cognitive function and quality of life of the drug combination group were significantly improved compared with the single drug group（ P〈0. 05）. Conclusion： The effect of tolbutamide will benefit with olanzapine on cognitive function of schizophrenia patients,can effectively improve the cognitive function of patients with clinical symptoms and improve the quality of life and promote the patients after treatment,to alleviate the suffering of patients and the burden of family and society are of great significance.