激素替代治疗围绝经期综合征的临床分析

Clinical analysis of hormone replacement therapy for perimenopausal syndrome

目的探索激素替代疗法治疗围绝经期综合征的效果。方法选择2014年2月至2016年6月我院收治的围绝经期综合征患者中,随机选出150例为研究对象,根据治疗方法随机分为对照组和观察组各75例。对照组患者接受常规对症治疗,观察组患者接受激素替代疗法(雌、孕激素序贯治疗),比较两组患者治疗前和治疗3个周期时的Kupperman评分、激素水平和子宫内膜厚度。结果治疗3个周期时,观察组患者Kupperman评分(8.31±1.24)分,显著低于对照组患者(14.53±1.65)分,差异有统计学意义(t=-26.098,P<0.001);且FSH、LH水平显著高于对照组患者,E2水平显著低于对照组患者,差异均有统计学意义(P<0.05);此外,观察组患者的子宫内膜(3.42±0.16)mm,显著厚于对照组患者子宫内膜(2.76±0.23)mm,差异有统计学意义(t=-20.400,P<0.001)。结论激素替代疗法用于围绝经期综合征的治疗中效果确切,促进患者临床症状的缓解,改善激素水平。

Objective To explore the effect of hormone replacement therapy in the treatment of perimenopausal syndrome.Methods From February 2014 to June 2016,150 cases patients with perimenopausal syndrome in our hospital were randomly selected as the research object. According to the difference of treatment the patients were divided into control group and observation group, the control group was given routine symptomatic treatment,the observation group was given hormone replacement therapy（estrogen and progesterone sequential therapy）. The Kupperman score,hormone levels and endometrial thickness were compared between the two groups before and during the 3 cycles of treatment. Results After 3 cycles of treatment,The Kupperman symptom score of observation group（8.31±1.24） was lower than the control group（14.53±1.65）,the difference was statistically significant（t =-26.098,P〈0.001）. The concentration of LH and FSH in observation group were statistically higher than those in the control group,the E2 value was lower than that of the control group（P 〈0.05）. The endometrial thickness of the observation group（3. 42 ± 0. 16mm） was thicker than that of the control group（2.76± 0. 23mm）（P 〈0.05）. Conclusions Hormone replacement therapy is effective in the treatment of perimenopausal syndrome. It can promote the remission of clinical symptoms and improve the hormone level,which is worthy of clinical application.