摘要
摘要: 目的探讨人工泪液凝胶+双氯芬酸钠滴眼液治疗干眼症的临床疗效.方法选取干眼症患者110例进行研究,按随机数字表法分为研究组(人工泪液凝胶+双氯芬酸钠)和对照组(人工泪液凝胶),治疗20 d后两组泪膜破裂时间(BUT)、角膜荧光素染色(FS)、泪液分泌试验(SIT)、心理状态、症状评分及临床疗效.结果研究组治疗总有效率为90.48%,对照组为75.24%,差异有统计学意义(x2=8.582,P〈0.05).治疗后研究组FS[(0.87±0.15)分比(1.53±0.84)分]低于对照组,BUT[(9.86±1.13)s比(5.71±1.27)s]与SIT[(6.85±1.59)mm/5 min比(4.38±2.07)mm/5 min]高于对照组,差异均有统计学意义(t=7.926、21.352、9.697,均P〈0.05).治疗后研究组症状评分较对照组低,差异有统计学意义[(8.39±3.24)分比(12.85±3.42)分](t=9.701,P〈0.05).治疗后研究组SDS抑郁自评量表评分[(37.16±5.63)分比(56.49±6.14)分]与SAS焦虑自评量表评分[(35.24±5.38)分比(54.30±6.42)分]较对照组低,且差异均有统计学意义(t=23.777、23.317,均P〈0.05).结论双氯芬酸钠与人工泪液凝胶联合应用可快速改善干眼症临床症状,提高治疗有效性.
Objective To investigate the clinical effects of artificial tear gel combined with diclofenac sodium in the treatment with xerophthalmia.Methods 110 patients with xerophthalmia were chosen as study subjects,and they were divided into research group(artificial tear gel + diclofenac sodium)and control group(artificial tear gel).BUT,FS,SIT,mental statue,symptom score and clinical effects after 20 days were compared between the two groups.Results The total effective rate of research group was 90.48%,which of the control group was 75.24%,the difference was statistically significant(x2=8.582,P〈0.05).The FS[(0.87±0.15)points vs.(1.53±0.84)points]of the research group was lower than that of the control group after treatment,and the BUT[(9.86±1.13)s vs.(5.71±1.27)s],SIT[(6.85±1.59)mm/5min vs.(4.38±2.07)mm/5min]of the research group were higher than those of the control group,the differences were statistically significant(t=7.926,21.352,9.697,all P〈0.05).After treatment,the symptom score of the research group was lower than that of the control group[(8.39±3.24)points vs.(12.85±3.42)points],the difference was statistically significant(t=9.701,P〈0.05).The SDS score [(37.16±5.63)points vs.(56.49±6.14)points]and SAS score[(35.24±5.38)points vs.(54.30±6.42)points]of the research group were lower than those of the control group after treatment,and the differences were statistically significant(t=23.777,23.317,all P〈0.05).Conclusion Artificial tear gel combined with diclofenac sodium can rapidly improve the clinical symptom of xerophthlmia and treatment effect.
出处
《中国基层医药》
CAS
2017年第16期2469-2472,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
干眼病
双氯芬酸钠
人工泪液凝胶
Xerophthalmia
Diclofenac sodium
Artificial tear gel