以宿主为靶点的抗乙型肝炎病毒药物的研究进展

Research progress for several host - targeting agents of anti - HBV

目前开发用于治疗乙型肝炎病毒（HBV）感染的靶点很多,既有针对宿主,也有针对病毒本身,但现有的临床药物只能抑制HBV复制,而不能清除HBV,尤其是cccDNA.因此HBV慢性持续感染所致的相关性疾病仍严重威胁着人类的健康.人们对于新型有效的抗HBV感染药物的研发仍迫不及待.本研究对新近几种以宿主为靶点的抗HBV药物的研究近况进行综述.

 Currently,there are a lot of targets for the treatment of HBV infection,both for the host,and for the virus itself.However,existed clinical drugs can only control HBV infection,and can not remove the HBV,especially cccDNA.Therefore,the chronic persistent infection caused by HBV related diseases is still seriously threat to human health.People are still impatient for the development of new effective anti-HBV drugs.In this paper,we review the recent research of the anti-hepatitis B virus based on the host as the target.