循环肿瘤细胞检测试剂的研究进展

Research Progress of Circulating Tumor Cell Detection Reagent

循环肿瘤细胞是原发肿瘤脱落后进入外周血中的肿瘤细胞。大量研究证明:其与肿瘤的进展有着密切的关系。通过检测和分析循环肿瘤细胞的特征、数量及变化,可用于肿瘤的诊断、治疗监测和预后评估。由于其微创、非侵入的获得方式,同时能够实时地评价肿瘤的动态,作为液态活检的一种方法备受关注。目前,市场上循环肿瘤细胞检测系统众多,主要包括分离富集和检测鉴定两部分。基于不同的原理,循环肿瘤细胞的检测结果差异较大。本文将简要介绍几种循环肿瘤细胞检测系统的原理和应用。

Circulating rumor cells （CTCs） are the tumor cells that shed from the primary site into the peripheral blood. A large number of studies have shown that CTCs have a close relationship with tumor progression in patients. It can be applied to the diagnosis, treatment monitoring and prognosis assessment of tumors by detecting and analyzing the characteristics, quantity and changes of CTCs. Because of its minimally invasive and non- invasive manner, real-time information of tumors can be evaluated. CTCs are the hot spot of cancer research and diagnosis as a method of liquid biopsy. So far, there have been many CTCs detection systems on the market, including two parts： enrichment and detection. Based on different principles, the detection results of CTCs are greatly different. This paper will briefly introduce the principle and application of several CTCs detection system.