PIPP与PTEN对黑色素瘤的抑制作用

Inhibitory effects of PIPP and PTEN on melanoma

黑色素瘤(melanoma)细胞周期的主要负调控物P21和P27的表达能被AKT信号通路抑制。黑色素瘤中BRAF基因产生了变异,且脯氨酸丰富的肌醇多磷酸5磷酸酶(PIPP)减少,使得PI3K/AKT途径活性增高。PIPP与PTEN有协同抑癌作用,PTEN通过催化磷脂酰肌醇3磷酸(PIP3)转化为PIP2来抑制PI3K/AKT途径。PIPP和PTEN的表达活性呈一定程度的正相关。

The expression of P21 and P27（ the main negative control material in the cell cycle of melanoma） can be suppressed by AKT signaling pathways. Both the BRAF gene mutation and the decrease of PIPP would lead to PI3K/AKT pathway activity rising in melanoma. PIPP and PTEN, both have a tumor suppressor role together, PTEN inhibites PI3K/AKT pathway by eatalyzing PIP3 to PIP2. The expression aetivity of PIPP and PTEN was positively correlated in a eertain degree.