350例口腔黏膜病患者龋患及其增龄改变的病例对照研究

Dental caries status and its age-related changes of 350 patients with oral mucosal disease:a case-control study

目的:本研究旨在调查口腔黏膜病患者的龋病检出情况及其增龄性改变,并探讨二者之间的相关性。方法:本研究采用病例对照研究设计,对350例口腔黏膜病患者以及351例健康人群进行患龋率、龋失补指数等临床指数进行调查及记录。结果:病例组的总患龋率(82.00%)高于对照组(73.50%),其中干燥综合征组患龋率最高(96.55%),复发性口腔溃疡组患龋率最低(72.86%),以60岁为界分组后患龋率无明显差异性(P>0.05);病例组总体龋失补指数(5.45±6.03)高于对照组(4.61±5.87),其中干燥综合征、口腔念珠菌病患者的龋失补指数显著高于对照组(P<0.05);以60岁为界分组后,病例组、灼口综合征、肉芽肿性唇炎及口腔念珠菌病的≥60岁龋失补指数显著高于≤59岁组。结论:本研究发现口腔黏膜病患者中一些疾病的龋患情况较对照组更为严重,其中干燥综合症、口腔念珠菌病及肉芽肿性唇炎组情况较为严重,这提示口腔医生应采取积极的防治措施以减少龋损对口腔黏膜病发病的影响和口腔黏膜病导致的龋患加剧。对于干燥综合征患者应尽早持续给予龋病防治措施,对于进入老年期的肉芽肿性唇炎、灼口综合征和口腔念珠菌病患者应给予积极的龋病防治措施。

Objective： This study aims to evaluate the dental caries status and its age-related changes of patients with oral mucosal disease. Methods： In this case-control study, 350 patients with oral mucosal disease and 351 matched systemically healthy controls were assessed prospectively in the clinical indexes, such as caries prevalence, and DMFT （decay missing filling index）. Results： The caries prevalence rate for case group （82.00%） was higher than that for control group （73.50%）. Moreover, caries prevalence rate of sjogren syndrome group was the highest （96.55%）, while caries prevalencerate of recurrent oral ulcer group was the lowest （72.86%）. Also, there was no significant difference in caries prevalence rate between patients who arc grouped based on the age of 60 （P~ 0,05）. DMFT of case group is a statistically significant higher than that of control group（5.45_＋ 6.03 versus 4.61_＋ 5.87）. DMFT of patients with sjogren syndrome （SS） and oral candidiasis is relatively higher than that of control group （P^0.05）. After patients are grouped based on the age of 60, patients （aged above 60） with burning mouth syndrome （BMS）, granulomatous cheilitis （GC） and oral candidiasis showed higher DMFT score than those who are aged below 59. Conclusion： Patients with some oral mucosal disease showed a serious dental caries status compared with healthy control group. Among them, patients of sjogren syndrome, oral candidiasis, andgranulomatous cheilitis had more serious dental caries status. It suggests that dentists should take active measures to reduce the impact of dental caries on the incidence of oral mucosal diseases or aggravated dental caries caused by oral mucosal disease. Patients with sjogren syndrome should be given caries prevention measures as early as possible. Besides, positive caries prevention measures play an important role in elderly patients with granulomatous cheilitis, burning mouth syndrome, and oral candidiasis.