阿司匹林对口腔NNIS 0级手术术后出血影响的Meta分析

The effect of aspirin on postoperative bleeding in patients undergoing oral NNIS 0 stage surgery A Meta-Analysis

目的:用循证医学的方法来评估单独口服阿司匹林的患者对口腔NNIS 0级手术术后出血情况的影响。方法:检索Pubmed及万方数据库,收集并筛选2007年1月1日至2016年12月31日期间的关于阿司匹林对口腔NNIS 0级术后出血情况影响的临床试验,并进行Meta分析。结果:共检索出98篇文献,经过筛选对纳入的5项研究进行Meta分析发现,口腔NNIS 0级手术前不停用阿司匹林对患者术后30min的出血情况无显著影响(相对危险度(odds ratio,OR)=1.23,95%可信区间(confidence interval,CI):0.90-1.68,p=0.211)。结论:低剂量(≤150mg/d)口服阿司匹林患者在口腔NNIS 0级手术前不需要停用药物。

Objective： To evaluate bleeding status of oral surgery with National Nosocomial Infection Surveillance risk index of 0 （NNIS 0） in patients on oral anticoagulated aspirin therapy using meta-analysis system. Methods： The PubMed and Wanfang databases were searched. Eligible studies were randomized controlled trials （RCTs） and controlled clinical trials on postoperative hemorrhage of continuation of aspirin before oral NNIS 0 surgery published from January 1, 2007 to December 31, 2016. Results： A total of 98 articles were retrieved and five studies were included in meta-analysis. The results showed no significant difference between patients on aspirin therapy and no oral anticoagulated therapy when postoperative bleeding were observed at 30 minutes （OR=1.23, 95%CI： 0.90-1.68, p=0.221）. Conclusions： We recommend not stopping use aspirin （~〈 150mg/d） before oral NNIS 0 surgery.