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程序性细胞死亡因子4在肿瘤中的研究进展 被引量：1

Research progress of programmed cell death 4 in tumors
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摘要 程序性细胞死亡因子4（PDCD4）为新近发现的抑癌基因,其表达受PDCD4基因甲基化、多种微小RNA的抑制.PDCD4编码的蛋白质可增强多种肿瘤细胞对抗肿瘤药物的敏感性,抑制肿瘤的发生发展和侵袭转移进程,在多种肿瘤中发挥重要作用,有望成为临床上判断肿瘤预后的重要指标. Programmed cell death 4 （PDCD4） is a newly discovered tumor suppressor gene, whose expression is regulated by methylation of PDCD4 gene and many kinds of microRNAs.Protein of PDCD4 enco-ding can improve the sensitivity of tumor cells to anticancer agents, inhibit tumor development and metastasis process, and play an important role in a variety of tumors.It is expected to be a clinical indicator to determine the prognosis of tumor.
作者 赵莉莉 张梅 朱耀东
机构地区 安徽医科大学附属省立医院中医肿瘤科
出处 《国际肿瘤学杂志》 CAS 2017年第7期512-515,共4页 Journal of International Oncology
基金 国家自然科学基金（81603439） 安徽省中医药科技项目（2016zy86）
关键词 肿瘤 程序性细胞死亡因子4 Neoplasms Programmed cell death 4
分类号 R730.2 [医药卫生—肿瘤]
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  • 2Wang Q, Sun Z, Yang HS. Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both beta-catenin/Tcf and AP-1- dependent transcription in colon carcinoma cells. Oncogene 2008; 27:1527-1535
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国际肿瘤学杂志
2017年 第7期

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