四跨膜蛋白在胃癌中的表达和意义

Expression and significance of tetraspanin in gastric cancer

四跨膜蛋白是一类表达非常广泛的细胞表面糖蛋白,可以与整合素、信号蛋白、生长因子等多种细胞表面分子结合并发挥功能.近年来越来越多的研究提示四跨膜蛋白与恶性肿瘤的侵袭、转移密切相关,并且显示出一定的临床价值,可作为恶性肿瘤诊断和预后的新指标.

Tetraspanins are a class of cell surface glycoproteins that are expressed very broadly, which can form a complex tetraspanins net by combining with many kinds of cell surface molecules such as integrins, signal proteins, growth factors and so on.In recent years, more and more studies suggest that tetraspanins are closely related to the invasion and metastasis of malignancies and show a certain clinical value, which can be used as new diagnosis and prognosis indicators of malignancy.