乳腺癌干细胞的治疗抵抗及其信号通路

Therapeutic resistance of breast cancer stem cells and its related signaling pathway

乳腺癌干细胞是导致乳腺癌治疗失败的主要原因,其在乳腺癌进展及复发耐药过程中发挥重要作用,与乳腺癌的放化疗、内分泌治疗抵抗等密切相关.其转移潜能及治疗抵抗与上皮间质转化及Hedgehog、Wnt、白细胞介素-6/信号传导与转录激活因子3、转化生长因子-β等多种信号通路相关,而针对这些信号通路的部分靶向药物也正进行临床转化研究,有望为乳腺癌的临床治疗提供新的方法.

Breast cancer stem cells （CSCs） are the main causes leading to the failure of treatment of breast cancer and play important roles in the progression of breast cancer and drug resistance, which are closely related to the therapeutic resistance of radiotherapy and chemotherapy, and endocrine therapy.The metastatic potential and therapeutic resistance of CSCs are associated with epithelial mesenchymal transition and Hedgehog, Wnt, interleukin-6/signal transduction and tanscriptional activation factor 3, transforming growth factor-β and other signaling pathways.While some of the targeted drugs targeting these signaling pathways are undergoing clinical transformation, which is expected to provide new approach for the clinical treatment of breast cancer.