质子治疗横纹肌肉瘤的研究进展

Research progress of proton therapy in rhabdomyosarcoma

横纹肌肉瘤（RMS）是儿童最常见的软组织肉瘤.放疗已成为RMS治疗的首选治疗方案之一,但可诱发严重的急性和晚期不良反应.质子治疗近年来越来越多的被应用于治疗RMS中.质子治疗安全有效,无严重不良反应.与常规射线比较,质子治疗RMS有物理学优势,可以更好地降低正常组织的受照剂量,提高患者生命质量.仍需要更多前瞻性研究和长期随访的临床结局,明确质子治疗应用于治疗RMS是否在晚期并发症的发生率和严重程度等方面优于光子治疗.

Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood.Radiation therapy has been integrated into the primary treatment of most patients with rhabdomyosarcoma, but which in turn potentially induces severe acute and late toxicities.Proton therapy in recent years has been more and more used in the treatment of rhabdomyosarcoma, which is safe and effective, with no serious adverse events.Compared with conventional photon therapy, proton therapy has distinct physical advantages and enables greater precision in the delivery of tumoricidal radiation doses with reduced irradiation of normal tissues, and improves quality of life for patients.Additional follow-up and prospectively studies are needed to determine whether proton therapy truly reduces the incidence and severity of late effects in comparison to patients treated with modern photon techniques.