氯吡格雷对急性心绞痛患者疗效及血清学指标的影响

Effect of clopidogrel on efficacy and serological markers of patients with acute angina

目的探讨氯吡格雷对急性心绞痛患者疗效及血清学指标的影响。方法选取80例急性心绞痛患者,随机分为对照组和研究组,每组各40例。对照组采用常规治疗,研究组在常规治疗的基础上加用氯吡格雷口服。比较两组的临床疗效,以及治疗前后的临床预后指标[(血清乳酸脱氢酶(LDH)和血压]、血清学指标(透明质酸、Ⅳ型胶原、板层素)水平。结果研究组治疗总有效率为95.0%,高于对照组的72.5%(P<0.05)。治疗后,两组收缩压及舒张压、血清LDH、透明质酸、Ⅳ型胶原、板层素水平均较前降低(P<0.05),且研究组以上指标水平均低于对照组(P<0.05)。结论对于急性心绞痛患者,常规药物加用氯吡格雷能更有效地改善症状并降低相关血清学指标,从而提高疗效。

Objective To explore the effect of clopidogrel on the efficacy and serological markers of patients with acute angina. Methods Eighty patients with acute angina were selected and were randomly divided into control group and study group, with 40 cases in each group. The control group received routine therapy,and the study group was orally administered elopidogrel on the basis of routine therapy. The clinical efficacy, the levels of clinical prognostic indicators [ including serum lactate dehydrogenase （LDH） and BP] and serological markers（ including hyaluronic acid, type IV collagen and laminin ） before and after treatment were compared between the two groups. Results The total effective rate of the study group was higher than that of the control group （95.0% vs. 72.5% ;P 〈 0.05）. After treatment,SBP and DBP, serum levels of LDH, hyaluronic acid ,type IV collagen and laminin decreased in both groups （P 〈 0.05 ）, and the levels of the indices above in the study group were lower than those in the control group （P 〈 0. 05）. Conclusion For the patients with acute angina,administration of clopidogrel plus routine medication can more effectively improve the symptoms and reduce the levels of relevant serological markers ,thus improve the efficacy.