ICS对慢性肥厚性鼻炎中转化生长因子β1表达的影响

The Impact of Inhaled Corticosteroids on Transformation Growth Factor β1 Expression in the Tissue of Chronic Hypertrophic Rhinitis

目的观察吸入性糖皮质激素(inhaled corticosteroids,ICS)对慢性肥厚性鼻炎黏膜组织中转化生长因子(TGF-β1)表达的影响。方法 20例慢性肥厚性鼻炎患者随机分为两组,实验组连续使用布地奈德混悬液雾化吸入1 w,对照组连续使用生理盐水雾化吸入1 w。所有患者雾化吸入前后分别取鼻腔黏膜行免疫组织化学染色,并做VAS法评估和鼻气道阻力测试。结果实验组ICS治疗前后鼻黏膜TGF-β1阳性细胞计数差值具有统计学意义(P<0.05);VAS鼻塞症状评分差值实验组为(2.60±0.37),对照组为(0.40±0.31),进行独立样本t检验,结果差异具有统计学意义(P<0.05);鼻气道总阻力差值无统计学意义。结论 ICS能降低慢性肥厚性鼻炎中TGF-β1的表达,能延缓鼻黏膜的纤维化进程。

Objective To observe the impact of inhaled corticosteroids （ICS） on transformation growth factor - beta 1 （ TGF-131 ） expression in the tissue of chronic hypertrophic rhinitis. Methods 20 patients with chronic hypertrophic rhinitis were randomlydivided into two groups. Patients in the experimental group received continuous aerosol inhalation of budesonide for one week, whilethose in the control group received continuous aerosol inhalation of normal saline for one week. All patients were given immunohisto-chemical staining of nasal mucosa before and after inhalation and nasal airway resistance test, and were evaluated by VAS. ResultsIn the experimental group, the difference of TGF- beta 1 positive cell count before and after ICS treatment was statistically significant（ P 〈 0. 05 ）. The difference of VAS nasal congestion symptom score was （2. 60 ± 0. 37） in the experimental group, （0.40 ± 0. 31 ）in the control group. In the test of independent sample t, the difference was statistically significant （ P 〈 O. 05 ）. There was no statisti-cally significant difference in total airway resistance between the nose and the airway. Conclusion ICS can reduce the expression ofTGF- beta 1 in chronic hypertrophic rhinitis and delay the process of fibrosis of nasal mucosa.