长期住院精神分裂症患者骨质疏松状况及其危险因素调查

Investigation of osteoporosis status and related risk factors in long-term hospitalized schizophrenic patients

目的:探讨长期住院精神分裂症患者骨质疏松(OP)状况及其危险因素。方法:对555例长期住院的精神分裂症患者进行骨密度测定,并据此分为OP组(376例)及非OP组(179例);比较两组一般人口学资料及临床资料,分析影响骨密度的主要因素。结果:555例长期住院的精神分裂症患者中OP发生率为67.7%(376例);与非OP组比较,OP组女性患者的比例及患者年龄显著增高(P<0.05或P<0.01);其中OP组男性患者体质量指数(BMI)明显低于非OP组男性(P<0.01);女性患者年龄及血糖水平明显高于非OP组女性(P均<0.01);多因素Logistic回归分析显示男性患者随着BMI值增高,OP发生率减低(P<0.01);女性患者随着年龄的增加OP发生率增加(P<0.05)。结论:长期住院的精神分裂症患者OP风险较高;低BMI和高龄分别是男性及女性精神分裂症患者OP危险因素。

Objective： To investigate the osteoporosis status（OP） and its risk factors in long-term hospitalized schizophrenic patients. Method： The bone mineral density was measured in 555 inpatients with schizophrenia,and then they were divided into OP group and non-OP group based on the result of the measurement.The general demographic and clinical data in the two groups were compared and the main factors affecting bone density were analyzed. Results： The incidence of OP in 555 schizophrenic patients with long-term hospitalization was 67. 7%（376 cases）. In the OP group the ratio of female and the age were significantly higher than those in the non-OP group（P 〈0. 05 or P 〈0. 01）; BMI of male was significantly lower than fale of the non-OP group（P 〈0. 01）; the age and blood glucose levels of female were significantly higher than those in female of the non-OP group（all P〈 0. 01）. Multivariate logistic regression analysis showed that in male patients the incidence of OP was decreased with the increase of BMI（P 〈0. 01）; the incidence of OP in female patients was increased with the increase of age（P 〈0. 05）. Conclusion： Long-term hospitalized schizophrenia patients present higher risk of OP; Low BMI in male patients and age in famale patinets are risk factors for OP of schizophrenic patients.