干扰素α1b雾化吸入佐治婴幼儿毛细支气管炎观察

Clinical efficacy of interferon α1b inhalation in adjuvant treatment of infantile bronchiolitis

目的:探讨干扰素α1b雾化吸入佐治婴幼儿毛细支气管炎的临床疗效。方法:以2015年1月至2016年3月期间我院收治的106例婴幼儿毛细支气管炎为研究对象,按随机数字表法分为2组,各53例。在综合治疗的基础上,对照组使用布地奈德和复方异丙托溴铵雾化治疗,治疗组使用布地奈德和复方异丙托溴铵并联合干扰素α1b雾化治疗。观察2组患儿雾化治疗后哮鸣音、咳嗽、肺部湿啰音消失时间并记录住院天数,治疗7 d后评定疗效。结果:治疗组患儿在哮鸣音消失时间、咳嗽消失时间、肺部湿啰音消失时间及住院时间方面与对照组比较明显缩短(P<0.01)。治疗组总有效率96.23%,对照组治疗总有效率83.02%,2组比较有显著性差异(P<0.05)。结论:在综合治疗的基础上使用干扰素α1b雾化吸入佐治婴幼儿毛细支气管炎,症状消失快,疗效显著,是临床值得推广的一种毛细支气管炎辅助治疗方法。

Objective： To investigate the clinical efficay of interferon α1b nebulization in the adjuvant treatment of infantile bronchiolitis. Methods： 106 infants with bronchiolitis were randomly divided into two groups,53 cases in each group.On the basis of comprehensive treatment,the control group was treated with budesonide and Compound Ipratropium Bromide nebulization while the treatment group was treated with budesonide and Compound Ipratropium Bromide combined with interferonα1b nebulization. The disappearance time of wheezing,cough and lung wet rales was observed; hospital day was recorded; the efficacy was evaluated in the two groups 7 days after the treatment. Results： The disappearance time of wheezing,cough and lung wet rales,and the length of stay in the treatment group were significantly shorter than those of the control group（ P〈0. 01）. The total effective rate of the treatment group was 96. 23%,which was significantly higher than that of the control group（ 83. 02%,P〈0. 05）. Conclusion： Interferon α1b nebulization on the basis of comprehensive therapy in the treatment of infantile bronchionlitis can quickly relieve the clinical symptoms and has obvious curative effect. It is an adjuvant therapy worthy of clinical promotion.