强化阿托伐他汀治疗对PCI术后ACS患者血脂水平的影响

Effect of intensive atorvastatin therapy on blood lipid levels in patients with acute coronary syndrome after PCI

目的:探讨强化阿托伐他汀治疗对行经皮冠状动脉介入治疗(PCI)术后急性冠脉综合征(ACS)患者血脂水平的影响。方法:选取2014年7月至2015年7月我院收治的110例PCI术后ACS患者作为研究对象,随机分成观察组与对照组,每组各55例。观察组患者在术后给予阿托伐他汀80 mg连续服用6个月;对照组患者在术后给予阿托伐他汀20 mg连续服用6个月。分别于术前和术后1个月、3个月、6个月空腹12 h后采血测定患者血脂水平,并比较2组患者的血脂水平及心血管事件发生率。结果:PCI术后1个月、术后3个月、术后6个月时,2组患者的TC、TG、LDL-C水平呈下降趋势,HDL-C水平呈上升趋势,与术前比较有显著性差异(P<0.05);并且,观察组TC、TG、LDL-C水平下降幅度较对照组大(P<0.05),HDL-C水平上升幅度较对照组大(P<0.05);观察组患者心血管事件发生率显著性低于对照组(P<0.05)。结论:强化阿托伐他汀治疗对PCI术后ACS患者有很好的降脂作用,且能降低术后并发症,值得临床推广。

Objective： To investigate the effect of intensive atorvastatin therapy on blood lipid levels in patients with acute coronary syndrome（ ACS） after percutaneous coronary intervention（ PCI）. Methods： 110 ACS patients admitted to our hospital from July 2014 to July 2015 were randomly divided into observation group and control group,55 cases in each group.Patients in the observation group took 80 mg atorvastatin for 6 months after operation,while those in the control group took20 mg atorvastatin for 6 months after operation. Blood lipid levels were measured before operation,1 month,3 months and 6months after operation,respectively. All blood samples were collected after 12 hours of fasting. Blood lipid levels and the incidence of cardiovascular events were compared between the two groups. Results： 1 month,3 months and 6 months after PCI,TC,TG and LDL-C levels showed a downward trend while HDL-C level showed an upward trend; compared with those before PCI,there were significant differences（ P〈0. 05）. Moreover,TC,TG and LDL-C levels of the observation group decreased more,and HDL level increased more significantly than those of the control group（ P〈0. 05）. The observation group showed lower incidence of cardiovascular events than that of the control group（ P〈0. 05）. Conclusion： Intensive atorvastatin therapy not only has a good lipid-lowering effect on ACS patients after PCI,but also can reduce the incidence of postoperative complications. It is worthy of clinical promotion.